ArticleJournal of medical case reports2018
Effect of high-flow high-volume-intermittent hemodiafiltration on metformin-associated lactic acidosis with circulatory failure: a case report.
Article in Journal of medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Severe Metformin Intoxication Resulting in Extreme Lactic Acidosis.Journal of medical cases · 2026Article
- Metformin-Associated Lactic Acidosis Induced by Even Modest Amounts of Alcohol: A Case Report.Cureus · 2025Article
- Metformin-associated Lactic Acidosis Induced by Excessive Alcohol Consumption.Internal medicine (Tokyo, Japan) · 2024Article
- Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.Journal of medical case reports · 2023Article
- A Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Article
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- Metformin-associated Lactic Acidosis Successfully Treated with Continuous Renal Replacement Therapy.Cureus · 2019Article
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetformin-associated lactic acidosis is a well-known life-threatening complication of metformin. We here report the case of a patient who developed metformin-associated lactic acidosis without organ manifestations, due to the simultaneous ingestion of an overdose of metformin and alcohol, and who recovered with high-flow high-volume intermittent hemodiafiltration. CASE PRESENTATION: A 44-year-old Asian woman with type 2 diabetes attempted suicide by ingesting 10 tablets of metformin 500 mg and drinking approximately 600 mL of Japanese sake containing 15% alcohol. She was transferred to our emergency department because of disturbed consciousness. Continuous intravenous administration of noradrenalin (0.13 μg/kg per minute) was given because she was in shock. Laboratory findings included a lactate level of 119 mg/dL (13.2 mmol/L), bicarbonate of 14.5 mmol/L, and serum metformin concentration of 1138 ng/mL. She was diagnosed as having metformin-associated lactic acidosis worsened by alcohol. After 4560 mL of bicarbonate ringer (Na
conclusionsHFHV-iHDF may be able to remove metformin and lactic acid efficiently and may improve the condition of hemodynamically unstable patients with metformin-associated lactic acidosis.
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Registered trials
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