Evidence map›Paper›PMID 30266073›Full record

ArticleHuman gene therapy2019

Efficient Reconstitution of Hepatic Microvasculature by Endothelin Receptor Antagonism in Liver Sinusoidal Endothelial Cells.

Neelam Yadav, Fadi Luc Jaber, Yogeshwar Sharma, Priya Gupta, Preeti Viswanathan, Sanjeev Gupta

Abstract read
In one paragraph

Article in Human gene therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Role of liver sinusoidal endothelial cells in liver diseases.Nature reviews. Gastroenterology & hepatology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Neelam Yadav1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Fadi Luc Jaber1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Yogeshwar Sharma1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Priya Gupta1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Preeti Viswanathan3 Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, New York.
Sanjeev Gupta1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Albert Einstein College of Medicine · US

Funding

Special Animal CoreP30DK041296 · NIDDK · YESHIVA UNIVERSITY · PI WOLKOFF, ALLAN W · 1989 to 2018
$22.9M
Transplantation of Endothelial CellsR01DK071111 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GUPTA, SANJEEV · 2006 to 2016
$3.6M
NIDDK NIH HHS P30 DK041296NIDDK NIH HHS R01 DK071111
6 · The paper itself

Abstract

Reconstitution of healthy endothelial cells in vascular beds offers opportunities for mechanisms in tissue homeostasis, organ regeneration, and correction of deficient functions. Liver sinusoidal endothelial cells express unique functions, and their transplantation is relevant for disease models and for cell therapy. As molecular targets for improving transplanted cell engraftment and proliferation will be highly significant, this study determined whether ET

Indexed as

AnimalsCell SurvivalCytoskeletonDipeptidyl Peptidase 4DNA DamageEndothelial CellsEndothelin Receptor AntagonistsLiverMembrane Potential, MitochondrialMiceMice, KnockoutMicrovesselsMitochondria, LiverModels, BiologicalOxidative StressReactive Oxygen SpeciesDipeptidyl Peptidase 4Endothelin Receptor AntagonistsReactive Oxygen Speciesataxia telangiectasia mutatedcell therapycytoprotectionDNA damagemitochondria

Identifiers

PMID30266073
PMCPMC6437629
OpenAlexW2893520077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.