Evidence map›Paper›PMID 30265900›Full record

ArticleBiomaterials2018

Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture.

Xuanyi Ma, Claire Yu, Pengrui Wang, Weizhe Xu, Xueyi Wan, Cheuk Sun Edwin Lai, Justin Liu, Anna Koroleva-Maharajh, Shaochen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Advances in Engineering Human Tissue Models.Frontiers in bioengineering and biotechnology · 2020
    Pooled it
  2. Review
  3. Article
  4. Review
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  6. Review
  7. Review
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  9. Review
  10. Microengineered Gradient Hydrogels for Mechanobiology.Advanced healthcare materials · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  18. Lithography-based 3D printing of hydrogels.Nature reviews bioengineering · 2025
    Article
  19. Review
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuanyi MaDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Claire YuDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Pengrui WangMaterials Science and Engineering Program, University of California, San Diego, La Jolla, CA, 92093, USA.
Weizhe XuDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Xueyi WanDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.
Cheuk Sun Edwin LaiChemical Engineering Program, University of California, San Diego, La Jolla, CA, 92093, USA.
Justin LiuMaterials Science and Engineering Program, University of California, San Diego, La Jolla, CA, 92093, USA.
Anna Koroleva-MaharajhDepartment of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Shaochen ChenDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA; Department of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA; Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA, 92093, USA; Chemical Engineering Program, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: chen168@eng.ucsd.edu.

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Rapid 3D bioprinting of biomimetic vascularized tissue constructsR01EB021857 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, DOKMECI, MEHMET REMZI · 2016 to 2019
$2.1M
Rapid 3D-printing of Multi-functional Adaptive Nerve ConduitsR33HD090662 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2021
$1.1M
Rapid 3D-printing of Multi-functional Adaptive Nerve ConduitsR21HD090662 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2017 to 2018
$382k
NIBIB NIH HHS R01 EB021857NICHD NIH HHS R21 HD090662NICHD NIH HHS R33 HD090662NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands. Scaffolds that can provide a 3D cirrhotic mechanical environment with complex native composition and biomimetic architecture are necessary for the development of better predictive tissue models. Here, we developed photocrosslinkable liver decellularized extracellular matrix (dECM) and a rapid light-based 3D bioprinting process to pattern liver dECM with tailorable mechanical properties to serve as a platform for HCC progression study. 3D bioprinted liver dECM scaffolds were able to stably recapitulate the clinically relevant mechanical properties of cirrhotic liver tissue. When encapsulated in dECM scaffolds with cirrhotic stiffness, HepG2 cells demonstrated reduced growth along with an upregulation of invasion markers compared to healthy controls. Moreover, an engineered cancer tissue platform possessing tissue-scale organization and distinct regional stiffness enabled the visualization of HepG2 stromal invasion from the nodule with cirrhotic stiffness. This work demonstrates a significant advancement in rapid 3D patterning of complex ECM biomaterials with biomimetic architecture and tunable mechanical properties for in vitro disease modeling.

Indexed as

Biocompatible MaterialsBiomechanical PhenomenaBioprintingCell ProliferationCell SurvivalDisease ProgressionExtracellular MatrixHep G2 CellsHumansLiverLiver NeoplasmsPrinting, Three-DimensionalTime FactorsTissue ScaffoldsBiocompatible Materials3D bioprintingCancer invasionDecellularized extracellular matrixLiver fibrosisTissue engineering

Identifiers

PMID30265900
PMCPMC6186504

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.