ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
Trauma exposure acutely alters neural function during Pavlovian fear conditioning.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Violence exposure moderates stress-elicited neurobehavioral function in young people.Emotion (Washington, D.C.) · 2026Article
- Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- Traumatic stress alters neural reactivity to visual stimulation.NPP - digital psychiatry and neuroscience · 2025Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Probing the neurocardiac circuit in trauma and posttraumatic stress.Journal of psychiatric research · 2024Article
- Investigating neural markers of Alzheimer's disease in posttraumatic stress disorder using machine learning algorithms and magnetic resonance imaging.Frontiers in neurology · 2024Article
- Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure.Molecular psychiatry · 2023Article
- Aberrant white matter microstructure evaluation by automated fiber quantification in typhoon-related post-traumatic stress disorder.Brain imaging and behavior · 2023Article
- Sequential fear generalization and network connectivity in trauma exposed humans with and without psychopathology.Communications biology · 2022Article
- Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.Translational psychiatry · 2022Article
- White matter diffusivity and its correlations to state measures of psychopathology in male refugees with posttraumatic stress disorder.NeuroImage. Clinical · 2022Article
- Hippocampal activation during contextual fear inhibition related to resilience in the early aftermath of trauma.Behavioural brain research · 2021Article
- Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Stress-elicited neural activity in young adults varies with childhood sexual abuse.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Preliminary study examining the mediational link between mild traumatic brain injury, acute stress, and post-traumatic stress symptoms following trauma.European journal of psychotraumatology · 2020Article
- The interaction between stress and chronic pain through the lens of threat learning.Neuroscience and biobehavioral reviews · 2019Review
- Neural correlates of oxytocin and cue reactivity in cocaine-dependent men and women with and without childhood trauma.Psychopharmacology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is associated with dysfunction of the neural circuitry that supports fear learning and memory processes. However, much of what is known about neural dysfunction in PTSD is based on research in chronic PTSD populations. Less is known about neural function that supports fear learning acutely following trauma exposure. Determining the acute effects of trauma exposure on brain function would provide new insight into the neural processes that mediate the cognitive-affective dysfunction associated with PTSD. Therefore, the present study investigated neural activity that supports fear learning and memory processes in recently Trauma-Exposed (TE) and Non-Trauma-Exposed (NTE) participants. Participants completed a Pavlovian fear conditioning procedure during functional magnetic resonance imaging (fMRI). During fMRI, participants' threat expectancy was continuously monitored. NTE participants showed greater threat expectancy during warning than safety cues, while no difference was observed in the TE group. This finding suggests TE participants overgeneralized the fear association to the safety cue. Further, only the TE group showed a negative relationship between fMRI signal responses within dorsomedial prefrontal cortex (PFC) and threat expectancy during safety cues. These results suggest the dorsomedial PFC mediates overgeneralization of learned fear as an acute result of trauma exposure. Finally, neural activity within the PFC and inferior parietal lobule showed a negative relationship with PTSD symptom severity assessed three months posttrauma. Thus, neural activity measured acutely following trauma exposure predicted future PTSD symptom severity. The present findings elucidate the acute effects of trauma exposure on cognitive-affective function and provide new insight into the neural mechanisms of PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.