ArticleLangmuir : the ACS journal of surfaces and colloids2019
Systematic Comparison of Zwitterionic and Non-Zwitterionic Antifouling Polymer Brushes on a Bead-Based Platform.
Article in Langmuir : the ACS journal of surfaces and colloids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 120 citations in OpenAlex.
- XPS analysis of polymer brush coatings.Polymer chemistry · 2026Review
- Exploring the Interactions Between Methyl Methacrylate Polymers and the Bacterial Outer Membrane via Coarse-Grained Molecular Dynamics Simulations.Journal of chemical information and modeling · 2026Article
- Epitope-Imprinted Polymers for Selective Recognition of Bacterial Proteins: From Design to Analytical Applications.ACS measurement science au · 2026Review
- Forward Osmosis for Produced Water Treatment: Comparative Performance Evaluation of Fabricated and Commercial Membranes.Polymers · 2026Article
- Formation and Characterization of Stable Antifouling Colloidal Particles via Surface-Initiated-Photoinduced Electron Transfer-Reversible Addition-Fragmentation Chain-Transfer Polymerization for Standardized Biophysical Measurements.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Antifouling Activity of Bottlebrush Network Hydrogels.ACS applied bio materials · 2025Article
- Grafting of Zwitterionic Polymers on Zirconia Surfaces: An XPS Investigation.Materials (Basel, Switzerland) · 2025Article
- Metal Nanocomposites as Biosensors for Biological Fluids Analysis.Materials (Basel, Switzerland) · 2025Review
- Complex Self-Organization inLangmuir : the ACS journal of surfaces and colloids · 2025Article
- A green, versatile, and facile strategy for anti-biofouling surface with ultra-high graft density polyethylene glycol.Journal of nanobiotechnology · 2024Article
- Tunable Cell-Adhesive Surfaces by Surface-Initiated Photoinduced Electron-Transfer-Reversible Addition-Fragmentation Chain-Transfer Polymerization.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties.Nature communications · 2024Article
- A streamlined proximity extension assay using POEGMA polymer-coated magnetic beads for enhanced protein detection.Frontiers in bioengineering and biotechnology · 2024Article
- Simulation-based assessment of zwitterionic pendant group variations on the hemocompatibility of polyethersulfone membranes.Functional composite materials · 2024Article
- Advances in Bioresorbable Triboelectric Nanogenerators.Chemical reviews · 2023Review
- SI-PET-RAFT in flow: improved control over polymer brush growth.Polymer chemistry · 2023Article
- Modular Design for Proteins Assembling into Antifouling Coatings: Case of Gold Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating.ACS omega · 2022Article
- Fundamentals and Applications of Polymer Brushes in Air.ACS applied polymer materials · 2022Review
- Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow.Membranes · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonspecific adsorption of biomolecules to solid surfaces, a process called biofouling, is a major concern in many biomedical applications. Great effort has been made in the development of antifouling polymer coatings that are capable of repelling the nonspecific adsorption of proteins, cells, and micro-organisms. In this respect, we herein contribute to understanding the factors that determine which polymer brush results in the best antifouling coating. To this end, we compared five different monomers: two sulfobetaines, a carboxybetaine, a phosphocholine, and a hydroxyl acrylamide. The antifouling coatings were analyzed using our previously described bead-based method with flow cytometry as the read-out system. This method allows for the quick and automated analysis of thousands of beads per second, enabling fast analysis and good statistics. We report the first direct comparison made between a sulfobetaine with opposite charges separated by two and three methylene groups and a carboxybetaine bearing two separating methylene groups. It was concluded that both the distance between opposite charges and the nature of the anionic groups have a distinct effect on the antifouling performance. Phosphocholines and simple hydroxyl acrylamides are not often compared with the betaines. However, here we found that they perform equally well or even better, yielding the following overall antifouling ranking: HPMAA ≥ PCMA-2 ≈ CBMAA-2 > SBMAA-2 > SBMAA-3 ≫ nonmodified beads (HPMAA being the best).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.