Evidence map›Paper›PMID 30265237›Full record

ArticleThe Journal of general virology2018

Nucleotide triphosphatase and RNA chaperone activities of murine norovirus NS3.

Kang Rok Han, Ji-Hye Lee, Giri Gowda Kotiguda, Kyoung Ho Jung, Mi Sook Chung, Soowon Kang, Seungmin Hwang, Kyung Hyun Kim

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Enzymatic Assays to Explore Viral mRNA Capping Machinery.Chembiochem : a European journal of chemical biology · 2021
    Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kang Rok Han1​Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea.
Ji-Hye Lee1​Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea.
Giri Gowda Kotiguda1​Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea.
Kyoung Ho Jung1​Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea.
Mi Sook Chung2​Department of Food and Nutrition, Duksung Women's University, Seoul 132-714, Republic of Korea.
Soowon Kang3​Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Seungmin Hwang3​Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Kyung Hyun Kim1​Department of Biotechnology and Bioinformatics, Korea University, Sejong 339-700, Republic of Korea.
Korea University · KRUniversity of Chicago · USDuksung Women's University · KR

Funding

Novel antiviral activity of interferon-gamma against viral replication complexR01AI127518 · NIAID · UNIVERSITY OF CHICAGO · PI RANDALL, GLENN C · 2017 to 2020
$1.6M
Targeting by autophagy proteins for anti-tumor immunityDP2CA225208 · NCI · UNIVERSITY OF CHICAGO · PI HWANG, SEUNGMIN · 2017 to 2017
$510k
NCI NIH HHS DP2 CA225208NIAID NIH HHS R01 AI127518
6 · The paper itself

Abstract

Modulation of RNA structure is essential in the life cycle of RNA viruses. Immediate replication upon infection requires RNA unwinding to ensure that RNA templates are not in intra- or intermolecular duplex forms. The calicivirus NS3, one of the highly conserved nonstructural (NS) proteins, has conserved motifs common to helicase superfamily 3 among six genogroups. However, its biological functions are not fully understood. In this study we report the oligomeric state and the nucleotide triphosphatase (NTPase) and RNA chaperone activities of the recombinant full-length NS3 derived from murine norovirus (MNV). The MNV NS3 has an Mg

Indexed as

AnimalsCations, DivalentCell LineCoenzymesHumansMagnesiumManganeseMiceMolecular ChaperonesNorovirusNucleoside-TriphosphataseProtein MultimerizationRecombinant ProteinsRNA, Double-StrandedRNA, ViralViral Nonstructural ProteinsCations, DivalentCoenzymesMagnesiumManganeseMolecular ChaperonesNucleoside-TriphosphataseRecombinant ProteinsRNA, Double-StrandedRNA, ViralViral Nonstructural ProteinshelicasenorovirusNS3NTPaseRNA chaperoneRNA replication

Identifiers

PMID30265237
PMCPMC7011751
OpenAlexW2894151328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.