Evidence map›Paper›PMID 30264654›Full record

ArticleEpigenetics2018

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins.

Yunzhang Wang, Robert Karlsson, Erik Lampa, Qian Zhang, Åsa K Hedman, Malin Almgren, Catarina Almqvist, Allan F McRae, Riccardo E Marioni, Erik Ingelsson and 7 more

Open access · bronzeAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Pooled it
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  18. Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Yunzhang Wanga Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0003-1165-3595
Robert Karlssona Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0002-8949-2587
Erik Lampab Department of Medical Sciences , Cardiovascular Epidemiology, Uppsala University , Uppsala , Sweden.
Qian Zhangc Institute for Molecular Bioscience , The University of Queensland , Brisbane , Australia.ORCID 0000-0002-0769-1057
Åsa K Hedmand Department of Medical Sciences , Molecular Epidemiology and Science for Life Laboratory, Uppsala University , Uppsala , Sweden.ORCID 0000-0001-5413-204X
Malin Almgrenf Department of Clinical Neuroscience , Centrum for Molecular Medicine, Karolinska Institutet , Stockholm , Sweden.
Catarina Almqvista Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Allan F McRaec Institute for Molecular Bioscience , The University of Queensland , Brisbane , Australia.
Riccardo E Marionih Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine , University of Edinburgh , Edinburgh , United Kingdom.ORCID 0000-0003-4430-4260
Erik Ingelssond Department of Medical Sciences , Molecular Epidemiology and Science for Life Laboratory, Uppsala University , Uppsala , Sweden.
Peter M Visscherc Institute for Molecular Bioscience , The University of Queensland , Brisbane , Australia.
Ian J Dearyi Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology , University of Edinburgh , Edinburgh , United Kingdom.
Lars Lindb Department of Medical Sciences , Cardiovascular Epidemiology, Uppsala University , Uppsala , Sweden.
Tiffany Morrism Cancer Institute , University College London , London , United Kingdom.
Stephan Beckm Cancer Institute , University College London , London , United Kingdom.
Nancy L Pedersena Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0001-8057-3543
Sara Hägga Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0002-2452-1500
Karolinska Institutet · SEUppsala University · SEThe University of Queensland · AUUniversity College London · GBEdinburgh Cancer Research · GBKarolinska University Hospital · SEUniversity of Edinburgh · GB

Funding

GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskR01AG028555 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI REYNOLDS, CHANDRA A · 2007 to 2010
$1.1M
Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/K026992/1NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG028555Wellcome Trust
6 · The paper itself

Abstract

Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P<1.3×10

Indexed as

DNA MethylationEpigenesis, GeneticAgedAgingCpG IslandsFemaleGenome-Wide Association StudyHumansMaleTwins, DizygoticTwins, MonozygoticagingDNA methylationlongitudinal studymeQTLtwin-pair analysis

Identifiers

PMID30264654
PMCPMC6284777
OpenAlexW2773928492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.