ArticleJournal of biomedical optics2018
Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy.Journal of biophotonics · 2026Article
- Imaging the mechanical properties of a developing embryonic tendon using Brillouin microscopy.Acta biomaterialia · 2025Article
- In-situ, real-time monitoring of thermo-mechanical properties of biological tissues undergoing laser heating and ablation.Biomedical optics express · 2024Article
- Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Porcine vocal fold elasticity evaluation using Brillouin spectroscopy.Journal of biomedical optics · 2023Article
- Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy.Neurophotonics · 2023Article
- Article
- Thermo-Visco-Elastometry of RF-Wave-Heated and Ablated Flesh Tissues Containing Au Nanoparticles.Biosensors · 2022Article
- Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications.Biosensors · 2022Review
- Article
- Acoustic, Phononic, Brillouin Light Scattering and Faraday Wave-Based Frequency Combs: Physical Foundations and Applications.Sensors (Basel, Switzerland) · 2022Review
- Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects.Frontiers in bioengineering and biotechnology · 2022Article
- Brillouin Spectroscopy: From Biomedical Research to New Generation Pathology Diagnosis.International journal of molecular sciences · 2021Review
- Mechano-chemistry of human femoral diaphysis revealed by correlative Brillouin-Raman microspectroscopy.Scientific reports · 2020Article
- High-sensitivity and high-specificity biomechanical imaging by stimulated Brillouin scattering microscopy.Nature methods · 2020Article
- Development and validation of hybrid Brillouin-Raman spectroscopy for non-contact assessment of mechano-chemical properties of urine proteins as biomarkers of kidney diseases.BMC nephrology · 2020Article
- SNR enhancement in brillouin microspectroscopy using spectrum reconstruction.Biomedical optics express · 2020Article
- Time-resolved Assessment of Drying Plants by Brillouin and Raman Spectroscopies.Journal of Raman spectroscopy : JRS · 2019Article
- Brillouin micro-spectroscopy of subchondral, trabecular bone and articular cartilage of the human femoral head.Biomedical optics express · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
Biomechanical properties of mammalian bones, such as strength, toughness, and plasticity, are essential for understanding how microscopic-scale mechanical features can link to macroscale bones' strength and fracture resistance. We employ Brillouin light scattering (BLS) microspectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins, and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free modality for probing viscoelastic properties of tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that MCS and BPMs are critically important for regeneration of elastic and viscous properties, respectively, HCF gels containing combination of all factors had the best effect with complete defect regeneration at week nine after the implantation of bone grafts and that the bones with fully consolidated fractures have higher values of elastic moduli compared with defective bones.
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Registered trials
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