ArticleNeuropsychopharmacology reports2018
Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain-intestine interactions.
Article in Neuropsychopharmacology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Novel Projections to the Cerebrospinal Fluid-Contacting Nucleus From the Subcortex and Limbic System in Rat.Frontiers in neuroanatomy · 2020Article
- Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain-intestine interactions.Neuropsychopharmacology reports · 2018Article
- Exposure to hot and cold environments increases noradrenaline release in the bed nucleus of the stria terminalis in rats.Neuropsychopharmacology reports · 2018Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
aimsThe bed nucleus of the stria terminalis (BNST) is a limbic structure mediating autonomic and neuroendocrine responses and negative affective states such as anxiety and fear. We previously demonstrated that noradrenergic transmission via β-adrenoceptors within the ventral part of BNST (vBNST) is involved in bidirectional interactions between the brain and the upper gastrointestinal (GI) tract. The present study aimed to examine the roles of intra-vBNST noradrenergic transmission via β-adrenoceptors in bidirectional interactions between the brain and lower GI tract.
methodsIn vivo microdialysis experiments were performed to examine colorectal distention (CRD)-induced noradrenaline release within the vBNST of freely moving male Sprague-Dawley rats. Colonic transit and abdominal pain perception were examined following intra-vBNST injections of isoproterenol, a β-adrenoceptor agonist, with and without co-administration of timolol, a β-adrenoceptor antagonist.
resultsCRD increased extracellular noradrenaline levels within the vBNST and evoked abdominal contractions in a pressure-dependent manner (30-60 mm Hg). Bilateral intra-vBNST injections of isoproterenol (30 nmol/side) significantly increased CRD (30 mm Hg)-induced abdominal contractions. Intra-vBNST injections of isoproterenol (30 nmol/side) significantly increased colonic transit, which was reversed by co-administration of timolol (30 nmol/side).
conclusionThe results of this study suggest (a) the existence of a positive feedback loop between intra-vBNST noradrenaline release and abdominal pain perception, and (b) the modulation of colonic motility by intra-vBNST noradrenergic transmission via β-adrenoceptors. Dysfunction of the lower GI tract may increase noradrenaline release within the vBNST, which, in turn, may exacerbate impairment of its motility and pain perception.
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