ArticleMovement disorders : official journal of the Movement Disorder Society2018
Task-specificity in focal dystonia is shaped by aberrant diversity of a functional network kernel.
Article in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03042962 (Brain Networks in Dystonia), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Networks in Dystonia
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Somato-Cognitive Action Network in Focal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Abnormal Brain Iron Metabolism is Linked to Altered Neural Function in Isolated Laryngeal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Neurobiology of Dystonia: Review of Genetics, Animal Models, and Neuroimaging.Brain sciences · 2025Review
- Increased functional connectivity of motor regions and dorsolateral prefrontal cortex in musicians with focal hand dystonia.Journal of neurology · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia.Neurobiology of disease · 2024Article
- Structural brain heterogeneity underlying symptomatic and asymptomatic genetic dystonia: a multimodal MRI study.Journal of neurology · 2024Article
- Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach.Neurology · 2023Article
- Temporal Signature of Task-Specificity in Isolated Focal Laryngeal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Clinical Implications of Dystonia as a Neural Network Disorder.Advances in neurobiology · 2023Review
- Deep Brain Stimulation for Pediatric Dystonia: A Review of the Literature and Suggested Programming Algorithm.Journal of child neurology · 2022Review
- Short- and Long-term Central Action of Botulinum Neurotoxin Treatment in Laryngeal Dystonia.Neurology · 2022Article
- Diagnostic Neurophysiologic Biomarkers for Task-Specific Dystonia.Movement disorders clinical practice · 2022Article
- Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities.Neurology · 2021Review
- Functional connectivity of the motor system in dystonia due to PKAN.eNeurologicalSci · 2021Article
- A novel task-specific dystonia type: Hemifacial spasm in a photographer.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Neural endophenotypes and predictors of laryngeal dystonia penetrance and manifestation.Neurobiology of disease · 2021Article
- Functional Neural Networks in Writer's Cramp as Determined by Graph-Theoretical Analysis.Frontiers in neurology · 2021Article
- A microstructural neural network biomarker for dystonia diagnosis identified by a DystoniaNet deep learning platform.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTask-specific focal dystonia selectively affects the motor control during skilled and highly learned behaviors. Recent data suggest the role of neural network abnormalities in the development of the pathophysiological dystonic cascade.
methodsWe used resting-state functional MRI and analytic techniques rooted in network science and graph theory to examine the formation of abnormal subnetwork of highly influential brain regions, the functional network kernel, and its influence on aberrant dystonic connectivity specific to affected body region and skilled motor behavior.
resultsWe found abnormal embedding of sensorimotor cortex and prefrontal thalamus in dystonic network kernel as a hallmark of task-specific focal dystonia. Dependent on the affected body region, aberrant functional specialization of the network kernel included regions of motor control management in focal hand dystonia (writer's cramp, musician's focal hand dystonia) and sensorimotor processing in laryngeal dystonia (spasmodic dysphonia, singer's laryngeal dystonia). Dependent on skilled motor behavior, the network kernel featured altered connectivity between sensory and motor execution circuits in musician's dystonia (musician's focal hand dystonia, singer's laryngeal dystonia) and abnormal integration of sensory feedback into motor planning and executive circuits in non-musician's dystonia (writer's cramp, spasmodic dysphonia).
conclusionsOur study identified specific traits in disorganization of large-scale neural connectivity that underlie the common pathophysiology of task-specific focal dystonia while reflecting distinct symptomatology of its different forms. Identification of specialized regions of information transfer that influence dystonic network activity is an important step for future delineation of targets for neuromodulation as a potential therapeutic option of task-specific focal dystonia. © 2018 International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.