ArticleAnnals of neurology2018
Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Article
- Operationalizing diffusion magnetic resonance imaging positivity for detection of vascular contributions to impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- White Matter Hyperintensity Burden and Short-Interval Change Associated With Sleep Apnoea in the UK Biobank.Annals of clinical and translational neurology · 2026Article
- Regional diffusion imaging measures to disentangle SVD-related hypertensive arteriopathy versus cerebral amyloid angiopathy.Molecular neurodegeneration · 2026Article
- Evaluating regional and global diffusion measures as biomarkers for vascular contributions to cognitive impairment and dementia.Cerebral circulation - cognition and behavior · 2026Article
- A simplified Fazekas scale for efficient assessment of white matter hyperintensities.Frontiers in neurology · 2026Article
- Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults.Neurology · 2025Article
- Longitudinal Changes in Brain Diffusion Characteristics Associated With Cognition and Vascular Risk Factors: The ARIC-NCS Study.Neurology · 2025Article
- Evaluation and interpretation of DTI-ALPS, a proposed surrogate marker for glymphatic clearance, in a large population-based sample.Alzheimer's research & therapy · 2025Article
- Plasma NfL and GFAP for predicting VCI and related brain changes in community and clinical cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sleep apnea physiological burdens and markers of white matter injury: the Multi-Ethnic Study of Atherosclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population?Alzheimer's research & therapy · 2024Article
- Choroid plexus volumes and auditory verbal learning scores are associated with conversion from mild cognitive impairment to Alzheimer's disease.Brain and behavior · 2024Article
- Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure.Annals of clinical and translational neurology · 2024Article
- Article
- White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition.Alzheimer's research & therapy · 2024Article
- Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression.CNS neuroscience & therapeutics · 2024Review
- Neuroimaging Characteristics of Hearing Loss in the Mayo Clinic Study of Aging.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Vascular risk, gait, behavioral, and plasma indicators of VCID.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
16 authors.
Funding
Abstract
objectiveRecent availability of amyloid and tau positron emission tomography (PET) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of Alzheimer disease (AD) pathologies. We wanted to quantify early cerebrovascular health-related magnetic resonance imaging brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health.
methodsWe used 2 independent samples (discovery, n = 390; validation, n = 1,035) of individuals, aged ≥ 60 years, along the cognitive continuum with imaging from the population-based sample of Mayo Clinic Study of Aging. We ascertained vascular health by summing up recently existing cardiovascular and metabolic conditions (CMC) from health care records (hypertension, hyperlipidemia, cardiac arrhythmias, coronary artery disease, congestive heart failure, diabetes mellitus, and stroke). Using multiple regression models, we quantified associations between CMC and brain health after accounting for age, sex, education/occupation, and AD burden (from amyloid and tau PET).
resultsSystemic vascular health was associated with medial temporal lobe thinning, widespread cerebral hypoperfusion, and loss of microstructural integrity in several white matter tracts including the corpus callosum and fornix. Further investigations suggested that microstructural integrity of the genu of the corpus callosum was suitable for assessing prodromal cerebrovascular health, had similar distributions in the discovery and independent validation datasets, and predicted cognitive performance above and beyond amyloid deposition.
interpretationSystemic vascular health has significant impact on brain structure and function. Quantifying prodromal cerebrovascular health-related brain measures that are independent of AD pathology-related changes has great utility for cognitive aging. Ann Neurol 2018;84:713-724.
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