Evidence map›Paper›PMID 30264294›Full record

ArticleMolecular neurobiology2019

Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain.

Juhee Agrawal, Birgit Ludwig, Bhaskar Roy, Yogesh Dwivedi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025
    Review
  2. Review
  3. Article
  4. Lipids and Suicide Risk.Current topics in behavioral neurosciences · 2020
    Article
  5. GABAFrontiers in neuroscience · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Juhee AgrawalDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC711 Sparks Center 1720 7th Avenue South, Birmingham, AL, 35294, USA.
Birgit LudwigDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC711 Sparks Center 1720 7th Avenue South, Birmingham, AL, 35294, USA.
Bhaskar RoyDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC711 Sparks Center 1720 7th Avenue South, Birmingham, AL, 35294, USA.
Yogesh DwivediDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC711 Sparks Center 1720 7th Avenue South, Birmingham, AL, 35294, USA. ydwivedi@uab.edu.ORCID http://orcid.org/0000-0002-5359-4717
University of Alabama at Birmingham · US

Funding

Plasma Exosomal MicroRNAs as Promising Novel Biomarkers for Suicidality and Treatment OutcomeR01MH107183 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH, SHELTON, RICHARD CHARLES · 2015 to 2019
$3.5M
MicroRNA Mapping in Major DepressionR01MH100616 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH · 2014 to 2019
$1.8M
Perturbed cell signaling network and suicide neurobiologyR01MH101890 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH · 2013 to 2017
$1.6M
Calcium Sensing Proteins in DepressionR01MH082802 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DWIVEDI, YOGESH · 2009 to 2013
$1.4M
National Institute of Mental Health 1R01MH107183National Institute of Mental Health R01MH082802National Institute of Mental Health R01MH100616National Institute of Mental Health R01MH101890NIMH NIH HHS R01 MH082802NIMH NIH HHS R01 MH100616NIMH NIH HHS R01 MH101890NIMH NIH HHS R01 MH107183
6 · The paper itself

Abstract

Testosterone is an anabolic androgenic steroid hormone involved in brain development, reproduction, and social behavior. Several studies have shown that testosterone can cause impulsivity in humans, which in turn, is linked with mood-related psychiatric disorders and higher risk of death by suicide. The mechanisms by which testosterone abuse influences impulsivity are unclear. The present study aims to understand how testosterone influences impulsivity in a rodent model both at behavioral and molecular levels. In this study, rats were either only gonadectomized or gonadectomized and injected with supraphysiological doses of testosterone. Their relative impulsivity levels were assessed using the go/no-go task. Serum level of testosterone was measured using ELISA. Transcript levels of alpha-2A adrenergic receptor (Adra2a), G proteins (stimulatory subunit-G

Indexed as

Signal TransductionAnimalsBrainGene Expression RegulationImpulsive BehaviorMaleRats, Long-EvansReceptors, Adrenergic, alpha-2TestosteroneTranscription, GeneticReceptors, Adrenergic, alpha-2TestosteroneAlpha-2A adrenergic receptorImpulsivityNoradrenergic systemRodent modelTestosterone

Identifiers

PMID30264294
PMCPMC6502699
OpenAlexW2893481489

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.