Evidence map›Paper›PMID 30264284›Full record

ReviewInternational journal of hematology2019

What do the lineage tracing studies tell us? Consideration for hematopoietic stem cell origin, dynamics, and leukemia-initiating cells.

Nathalia Azevedo Portilho, Michihiro Kobayashi, Momoko Yoshimoto

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nathalia Azevedo PortilhoCenter for Stem Cell and Regenerative Medicine at Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, 77030, USA.
Michihiro KobayashiCenter for Stem Cell and Regenerative Medicine at Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, 77030, USA.
Momoko YoshimotoCenter for Stem Cell and Regenerative Medicine at Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, 77030, USA. Momoko.Yoshimoto@uth.tmc.edu.ORCID http://orcid.org/0000-0002-7272-6682

Funding

Embryonic origin and self-renewal of B-1a cellsR01AI121197 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YOSHIMOTO, MOMOKO · 2016 to 2020
$1.9M
National Institute of Allergy and Infectious Diseases R01AI121197NIAID NIH HHS R01 AI121197
6 · The paper itself

Abstract

The recent advance of technologies enables us to trace the cell fate in vivo by marking the cells that express the gene of interest or by barcoding them at a single cell level. Various tamoxifen-inducible Cre-recombinase mice combined with Rosa-floxed lines are utilized. In this review, with the results revealed by lineage tracing assays, we re-visit the long-standing debate for the origin of hematopoietic stem cells in the mouse embryo, and introduce the view of native hematopoiesis, and possible leukemic-initiating cells emerged during fetal stages.

Indexed as

Cell LineageAnimalsCarcinogenesisEmbryo, MammalianHematopoiesisHematopoietic Stem CellsHumansLeukemiaMiceAGMHematopoietic stem cellsLineage tracingMouse embryoYolk sac

Identifiers

PMID30264284
PMCPMC6450395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.