ArticleNeuroradiology2018
White matter involvement in young non-demented Down's syndrome subjects: a tract-based spatial statistic analysis.
Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- White matter trajectories in Down syndrome and Alzheimer's disease: Insights from diffusion tensor-based morphometry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Enduring differential patterns of neuronal loss and myelination along 6-month pulsatile gonadotropin-releasing hormone therapy in individuals with Down syndrome.Brain communications · 2025Article
- Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome.Journal of neurodevelopmental disorders · 2024Article
- The mismatch negativity as an index of cognitive abilities in adults with Down syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer's disease (AD) neuropathology: A hypothesis and review.Frontiers in aging neuroscience · 2023Article
- Structural Connectivity in Down Syndrome and Alzheimer's Disease.Frontiers in neuroscience · 2022Review
- White matter microstructure associations to amyloid burden in adults with Down syndrome.NeuroImage. Clinical · 2022Article
- White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study.Journal of neurodevelopmental disorders · 2021Article
- Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.Brain : a journal of neurology · 2020Article
- Detection of microstructural white matter alterations in functional gastrointestinal disorders assessed by diffusion kurtosis imaging.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry.Scientific reports · 2020Article
- Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Review
- Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer's disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, without dementia, by means of DTI technique, compared to a normal control group.
methodsThe study group consisted of 17 right-handed subjects with DS and many control subjects. All individuals participating in this study were examined by MR exam including DTI acquisition (32 non-coplanar directions); image processing and analysis were performed using FMRIB Software Library (FSL version 4.1.9, http://www.fmrib.ox.ac.uk/fsl )) software package. Finally, the diffusion tensor was estimated voxel by voxel and the FA map derived from the tensor. A two-sample t test was performed to assess differences between DS and control subjects.
resultsThe FA is decreased in DS subjects, compared to control subjects, in the region of the anterior thalamic radiation, the inferior fronto-occipital fasciculum, the inferior longitudinal fasciculum, and the cortico-spinal tract, bilaterally.
conclusionsThe early white matter damage visible in our DS subjects could have great impact in the therapeutic management, in particular in better adapting the timing of therapies to counteract the toxic effect of the deposition of amyloid that leads to oxidative stress.
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