Evidence map›Paper›PMID 30263978›Full record

ReviewBJS open2018

Meta-analysis of the impact of postoperative complications on survival after oesophagectomy for cancer.

E Booka, H Takeuchi, K Suda, K Fukuda, R Nakamura, N Wada, H Kawakubo, Y Kitagawa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BJS open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Evaluating the impact of enhanced recovery after surgery protocols following oesophagectomy: a systematic review and meta-analysis of randomised clinical trials.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
    Pooled it
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  19. Current advances and challenges in minimally invasive esophagectomy.International journal of clinical oncology · 2025
    Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E BookaDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.ORCID 0000-0001-7413-5256
H TakeuchiDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.
K SudaDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.ORCID 0000-0002-0423-1565
K FukudaDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.
R NakamuraDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.
N WadaDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.
H KawakuboDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.
Y KitagawaDepartment of Surgery Keio University School of Medicine Tokyo Shizuoka Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOesophagectomy has a high risk of postoperative morbidity. The impact of postoperative complications on overall survival of oesophageal cancer remains unclear. This meta-analysis addressed the impact of complications on long-term survival following oesophagectomy.

methodsA search of PubMed and Cochrane Library databases was undertaken for systematic review of papers published between January 1995 and August 2016 that analysed the relation between postoperative complications and long-term survival. In the meta-analysis, data were pooled. The main outcome was overall survival (OS). Secondary endpoints included disease-free (DFS) and cancer-specific (CSS) survival.

resultsA total of 357 citations was reviewed; 21 studies comprising 11 368 patients were included in the analyses. Overall, postoperative complications were associated with significantly decreased 5-year OS (hazard ratio (HR) 1·16, 95 per cent c.i. 1·06 to 1·26; P = 0·001) and 5-year CSS (HR 1·27, 1·09 to 1·47; P = 0·002). Pulmonary complications were associated with decreased 5-year OS (HR 1·37, 1·16 to 1·62; P < 0·001), CSS (HR 1·60, 1·35 to 1·89; P < 0·001) and 5-year DFS (HR 1·16, 1·00 to 1·33; P = 0·05). Patients with anastomotic leakage had significantly decreased 5-year OS (HR 1·20, 1·10 to 1·30; P < 0·001), 5-year CSS (HR 1·81, 1·11 to 2·95; P = 0·02) and 5-year DFS (HR 1·13, 1·02 to 1·25; P = 0·01).

conclusionPostoperative complications after oesophagectomy, including pulmonary complications and anastomotic leakage, decreased long-term survival.

Identifiers

PMID30263978
PMCPMC6156161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.