ArticleSSM - population health2018
A multifaceted analysis of social stressors and chronic inflammation.
Article in SSM - population health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa.Brain, behavior, & immunity - health · 2026Article
- Age-dependent associations of psychological and family factors on systemic inflammation in childhood acute lymphoblastic leukemia survivors.Journal of cancer survivorship : research and practice · 2026Article
- Article
- Food Insecurity and Clinical Biomarkers of Inflammation among Cancer Survivors in the All of Us Research Program.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Relationship Between Family Support, C-Reactive Protein and Body Mass Index Among Outpatients with Schizophrenia.Healthcare (Basel, Switzerland) · 2025Article
- Molecular connections between inflammation and social determinants of health.Frontiers in epidemiology · 2025Review
- The psychosocial anti-inflammatories: Sense of control, purpose in life, and social support in relation to inflammation, functional health and chronic conditions in adulthood.Journal of psychosomatic research · 2024Article
- Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.Human molecular genetics · 2024Article
- Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins.The Prostate · 2022Review
- How social/environmental determinants and inflammation affect salivary telomere length among middle-older adults in the health and retirement study.Scientific reports · 2022Article
- Assessing the roles of demographic, social, economic, environmental, health-related, and political factors on risk of osteoporosis diagnosis among older adults.Archives of osteoporosis · 2021Article
- The Perfect Storm: COVID-19 Health Disparities in US Blacks.Journal of racial and ethnic health disparities · 2021Review
- Optimism, pessimism, and health biomarkers in older couples.British journal of health psychology · 2020Article
- Structural Inequity and Socioeconomic Status Link to Osteoporosis Diagnosis in a Population-Based Cohort of Middle-Older-Age Americans.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chronic stress has been linked to negative health outcomes, including increased inflammation, which can be measured by high-sensitivity C-reactive protein (CRP). Prior research has focused almost exclusively on relationships between individual social and demographic stressors and CRP. The objective of this study is to assess the role of multiple potential stressors simultaneously to determine which key stressors are related to risk of high CRP, given that sustained stress and resulting inflammation may have long-term health implications. We hypothesized that negative social and environmental factors would be associated with high CRP. Data from two waves of Midlife in the United States were used to predict high CRP with variable selection procedures and logistic regression. Results indicated females, those with greater BMI, those with improvements in family strain, and those with higher A1c had a greater risk of high CRP. There was limited evidence that negative social factors were associated with CRP to the extent seen in prior literature. A key advantage of the study was testing multiple potential determinants of chronic stress and inflammation simultaneously, advancing the existing literature. Results demonstrate the potential usefulness of a multifaceted approach to evaluating the risk of chronic inflammation and high CRP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.