Evidence map›Paper›PMID 30263672›Full record

ArticleFood science and biotechnology2017

Anti-inflammatory and anti-genotoxic activity of branched chain amino acids (BCAA) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages.

Jae Hoon Lee, Eunju Park, Hyue Ju Jin, Yunjeong Lee, Seung Jun Choi, Gyu Whan Lee, Pahn-Shick Chang, Hyun-Dong Paik

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The Complex Relation of Branched-Chain Amino Acids and Inflammation in the Obesity and Diabetes Context.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
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  11. Macrophage energy metabolism in cardiometabolic disease.Molecular and cellular biochemistry · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Metabolites · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jae Hoon Lee1Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029 Korea.
Eunju Park2Department of Food and Nutrition, Kyungnam University, Changwon, 51767 Korea.
Hyue Ju Jin1Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029 Korea.
Yunjeong Lee2Department of Food and Nutrition, Kyungnam University, Changwon, 51767 Korea.
Seung Jun Choi3Department of Food Science and Technology, Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul, 01811 Korea.
Gyu Whan LeeR&D Center, Daesang Corporation, Icheon, 17384 Korea.
Pahn-Shick Chang5Department of Agricultural Biotechnology, Center for Food and Bioconvergence, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826 Korea.
Hyun-Dong Paik1Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029 Korea.
Konkuk University · KRKyungnam University · KRSeoul National University · KRSeoul National University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to evaluate the anti-inflammatory and anti-genotoxic activity of branched-chain amino acids (BCAAs) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages. BCAAs inhibited LPS-induced NO production, with 100 mM leucine having the most pronounced effect, suppressing NO production by 81.15%. Valine and isoleucine also reduced NO production by 29.65 and 42.95%, respectively. Furthermore, BCAAs suppressed the inducible nitric oxide synthase mRNA expression. Additionally, BCAAs decreased the mRNA expression of interleukin-6 and cyclooxygenase-2 which are proinflammatory mediators. Anti-genotoxic activities of BCAAs were assessed using the alkaline comet assay and valine, isoleucine, and leucine significantly (

Indexed as

Anti-genotoxic activityAnti-inflammatory activityBranched-chain amino acidRAW 264.7 macrophage

Identifiers

PMID30263672
PMCPMC6049802
OpenAlexW2747976482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.