Evidence map›Paper›PMID 30263124›Full record

ArticlePharmacology research & perspectives2018

Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor.

Adam L Valkovic, Miranda B Leckey, Alice R Whitehead, Mohammed A Hossain, Asuka Inoue, Martina Kocan, Ross A D Bathgate

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells.International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Adam L ValkovicFlorey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Miranda B LeckeyFlorey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Alice R WhiteheadFlorey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Mohammed A HossainFlorey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Asuka InoueGraduate School of Pharmaceutical Sciences Tohoku University Aoba Miyagi Japan.
Martina KocanFlorey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Ross A D BathgateFlorey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.ORCID 0000-0001-6301-861X
The University of Melbourne · AUTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relaxin family peptide (RXFPs) 1-4 receptors modulate the activity of cyclic adenosine monophosphate (cAMP) to produce a range of physiological functions. RXFP1 and RXFP2 increase cAMP via Gα

Indexed as

Energy TransferBioluminescence Resonance Energy Transfer TechniquesBiosensing TechniquesCell LineCell Line, TumorCyclic AMPCytoplasmGene Knockdown TechniquesHEK293 CellsHumansLuminescent ProteinsReceptors, G-Protein-CoupledReceptors, PeptideRelaxinSignal TransductionTime FactorsCyclic AMPLuminescent ProteinsReceptors, G-Protein-CoupledReceptors, PeptideRelaxinrelaxin receptorscAMPCAMYELGPCRrelaxinRXFPsignalling

Identifiers

PMID30263124
PMCPMC6153321
OpenAlexW2892801139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.