Evidence map›Paper›PMID 30263008›Full record

ArticleInternational journal of biological sciences2018

Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients.

Hafiz Muhammad Ishaq, Imran Shair Mohammad, Muhammad Shahzad, Chaofeng Ma, Muhammad Asif Raza, Xiaokang Wu, Hui Guo, Peijie Shi, Jiru Xu

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04376203 (What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development?), which is not on this map. Cited by 70 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04376203 unknown statusnot on this mapstarted 2020, after this paper: background citation

What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development?

TypeobservationalSponsorUniversity of IoanninaRan2020 to 2023Enrolled40ConditionsPapillary Thyroid Microcarcinoma, MicrobiomeArmsThyroidectomy
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Microbiota and Thyroid Disease: An Updated Systematic Review.Advances in experimental medicine and biology · 2023
    Pooled it
  3. Pooled it
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  6. Pooled it
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  8. Trial
  9. Trial
  10. Article
  11. Review
  12. Article
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  15. Review
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  17. Association ofFrontiers in microbiology · 2026
    Article
  18. Gut microbiota alteration was related to subclinical hypothyroidism and dyslipidemia in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  19. Review
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hafiz Muhammad IshaqDepartment of Veterinary and Animal Sciences, Muhammad Nawaz Sharif University of Agriculture, Multan, Pakistan.
Imran Shair MohammadDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Muhammad ShahzadDepartment of Pharmacology, University of Health Sciences, Khyaban-e-Jamia Punjab, Lahore, Pakistan.
Chaofeng MaXi'an center for disease control and prevention, China.
Muhammad Asif RazaDepartment of Veterinary and Animal Sciences, Muhammad Nawaz Sharif University of Agriculture, Multan, Pakistan.
Xiaokang WuThe second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Street, Xi'an China.
Hui GuoDepartment of Endocrinology and metabolic diseases, 1st affiliated Hospital Xi'an Jiotong University, China.
Peijie ShiDepartment of Endocrinology and metabolic diseases, 1st affiliated Hospital Xi'an Jiotong University, China.
Jiru XuDepartment of Microbiology and Immunology, Key Laboratory of Environment and Genes Related to Diseases of Chinese Ministry of Education, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbial association with host co-existence is critical for body homeostasis and pathogenicity. Graves' disease (GD) is an autoimmune disease manifested with hyperthyroidism and ophthalmopathy. However, we hypothesized that gut bacteria could affect an important role in GD pathogenicity. The current study aim was to characterize and investigate the intestinal bacterial composition of GD qualitatively and quantitatively. 27 GD and 11 healthy controls were enrolled for fecal sample collection. The PCR-DGGE of 16S rRNA gene by targeting V3 region and Real-time PCR for

Indexed as

AdultFemaleGastrointestinal MicrobiomeGraves DiseaseHumansMaleMiddle AgedReal-Time Polymerase Chain ReactionSurveys and QuestionnairesDGGEGDGut microbiotaHigh-throughput sequencingHyperthyroidismOphthalmopathy

Identifiers

PMID30263008
PMCPMC6158725

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.