Evidence map›Paper›PMID 30262956›Full record

ArticleIndian journal of microbiology2018

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye.

Sama Kalyana Chakravarthy, Rajagopalaboopathi Jayasudha, Gumpili Sai Prashanthi, Mohammed Hasnat Ali, Savitri Sharma, Mudit Tyagi, Sisinthy Shivaji

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Indian journal of microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 111 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04322500 nacompletednot on this mapstarted 2019, after this paper: background citation

Intestinal Microbiota: a New Target for Chalaziosis Treatment in Children

TypeinterventionalSponsorUniversity of MoliseRan2019 to 2020Enrolled26ConditionsChalazionArmsprobiotics, conservative treatment
NCT04342507 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of Probiotic Oral Supplementation on the Treatment of Chalazion in Adults: a Pilot Study on 20 Patients

TypeinterventionalSponsorUniversity of MoliseRan2019 to 2020Enrolled20ConditionsChalazionArmsconservative treatment, probiotics
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 3 syntheses or guidelines pooled it, 203 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
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  7. Article
  8. Article
  9. Review
  10. Gut microbial interaction networks control autoimmunity to neuroretina.bioRxiv : the preprint server for biology · 2025
    Article
  11. Role of gut microbiomes in different ocular pathologies: A systematic review.World journal of gastrointestinal pathophysiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Microbiome-based therapeutics for ocular diseases.Clinical & experimental optometry · 2025
    Review
  20. Review

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sama Kalyana Chakravarthy1Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
Rajagopalaboopathi Jayasudha1Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
Gumpili Sai Prashanthi1Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
Mohammed Hasnat Ali2Clinical Epidemiology and Bio-Statistics, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
Savitri Sharma1Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
Mudit Tyagi3Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
Sisinthy Shivaji1Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034 India.
L V Prasad Eye Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveitis (UVT), an inflammatory disease of the eye significantly contributes to vision impairment and blindness. Uveitis is associated with systemic infectious and autoimmune diseases, but in most cases, the aetiology remains unidentified. Dysbiosis in the gut microbiome has been implicated in autoimmune diseases, inflammatory diseases, cancers and mental disorders. In a mice model of autoimmune UVT, it was observed that manipulating the gut microbiome reduces the inflammation and disease severity. Further, alterations in the bacterial gut microbiome and their metabolites were reported in UVT patients from a Chinese cohort. Hence, it is worth comparing the bacterial gut microbiome of UVT patients with that of healthy controls (HC) to ascertain whether dysbiosis of the gut microbiome has implications in UVT. Our analyses showed reduced diversity of several anti-inflammatory organisms including

Indexed as

DysbiosisGut microbiomeIllumina MiseqUveitisV3–V4 region of 16S rRNA gene

Identifiers

PMID30262956
PMCPMC6141402
OpenAlexW2806271612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.