Evidence map›Paper›PMID 30262916›Full record

ArticleScientific reports2018

A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice.

Alexis D Griffith, Asifa K Zaidi, Ashley Pietro, Matthew Hadiono, Jessica S Yang, Rachel Davis, Daniel L Popkin

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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  8. Identification ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexis D GriffithDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA.
Asifa K ZaidiDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA.
Ashley PietroDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA.
Matthew HadionoDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA.
Jessica S YangDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA.
Rachel DavisDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA.
Daniel L PopkinDepartment of Dermatology, Case Western Reserve University Hospitals, Cleveland, OH, 44106, USA. daniel.popkin@case.edu.
Case Western Reserve University · USUniversity Hospitals of Cleveland · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
Combating persistent viral infections using cell specific therapiesI01BX002719 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI POPKIN, DANIEL LEWIS · 2016 to 2018
–
BLRD VA I01 BX002719NCATS NIH HHS UL1 TR000439NIAID NIH HHS P30 AI036219NIAMS NIH HHS P30 AR039750
6 · The paper itself

Abstract

There is competing evidence that plasmacytoid dendritic cells (pDC), the most potent source of IFN-I, may initiate psoriasis. We targeted pDC function using the slc15a4

Indexed as

AnimalsCytokinesDermatitisDisease Models, AnimalImiquimodInflammationMembrane GlycoproteinsMembrane Transport ProteinsMiceMice, TransgenicPsoriasisSkinToll-Like Receptor 7CytokinesImiquimodMembrane GlycoproteinsMembrane Transport ProteinsSlc15a4 protein, mouseTlr7 protein, mouseToll-Like Receptor 7

Identifiers

PMID30262916
PMCPMC6160456
OpenAlexW2890644934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.