ArticleScientific reports2018
Parallelized, real-time, metabolic-rate measurements from individual Drosophila.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Direct quantification of the metabolic heat output of individual Drosophila brains.Cell reports methods · 2026Article
- Neuromorphic computing for robotic vision: algorithms to hardware advances.Communications engineering · 2025Review
- The development of ultrasensitive microcalorimeters for bioanalysis and energy balance monitoring.Fundamental research · 2024Review
- Micro-kelvin temperature-stable system for biocalorimetry applications.The Review of scientific instruments · 2024Article
- Molecular and Neural Mechanisms of Temperature Preference Rhythm inJournal of biological rhythms · 2023Review
- Measuring O2 Consumption in Drosophila Melanogaster using Coulometric Microrespirometry.Journal of visualized experiments : JoVE · 2023Article
- Article
- Metabolic decline in an insect ear: correlative or causative for age-related auditory decline?Frontiers in cell and developmental biology · 2023Article
- Measuring metabolic rate in single flies during sleep and waking states via indirect calorimetry.Journal of neuroscience methods · 2022Article
- Phenotyping ofBiomolecules · 2022Review
- Sub-nanowatt microfluidic single-cell calorimetry.Nature communications · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant recent evidence suggests that metabolism is intricately linked to the regulation and dysfunction of complex cellular and physiological responses ranging from altered metabolic programs in cancers and aging to circadian rhythms and molecular clocks. While the metabolic pathways and their fundamental control mechanisms are well established, the precise cellular mechanisms underpinning, for example, enzymatic pathway control, substrate preferences or metabolic rates, remain far less certain. Comprehensive, continuous metabolic studies on model organisms, such as the fruit fly Drosophila melanogaster, may provide a critical tool for deciphering these complex physiological responses. Here, we describe the development of a high-resolution calorimeter, which combines sensitive thermometry with optical imaging to concurrently perform measurements of the metabolic rate of ten individual flies, in real-time, with ~100 nW resolution. Using this calorimeter we have measured the mass-specific metabolic rates of flies of different genotypes, ages, and flies fed with different diets. This powerful new approach enables systematic studies of the metabolic regulation related to cellular and physiological function and disease mechanisms.
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