Trial reportScientific reports2018
Salience network structural integrity predicts executive impairment in alcohol use disorders.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Cognition, body, and mind: A three-in-one coordinate-based fMRI meta-analysis on cognitive, physical, and meditative trainings.Human brain mapping · 2023Pooled it
- Common abnormality of gray matter integrity in substance use disorder and obsessive-compulsive disorder: A comparative voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder.Scientific reports · 2021Pooled it
- Corticotropin-Releasing Factor receptor 1 (CRF1) antagonism in patients with alcohol use disorder and high anxiety levels: effect on neural response during Trier Social Stress Test video feedback.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Using deep learning to identify brain networks mediating cognitive and motor impairments in alcohol use disorder.Translational psychiatry · 2026Article
- Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.Human brain mapping · 2025Article
- Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study.Brain and behavior · 2025Article
- White matter neural substrates in alcohol dependence with genetic risk and their role in pathological reward process.Scientific reports · 2025Article
- Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region.Translational psychiatry · 2025Article
- Thiamine Deficiency and Neuroinflammation Are Important Contributors to Alcohol Use Disorder.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Altered Effective Connectivity During Threat Anticipation in Individuals With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence fromFrontiers in psychology · 2025Article
- Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.Addiction biology · 2024Article
- Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging.Translational psychiatry · 2024Article
- Early life stress and body-mass-index modulate brain connectivity in alcohol use disorder.Translational psychiatry · 2024Article
- The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research.Current addiction reports · 2024Review
- Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control.Frontiers in behavioral neuroscience · 2023Article
- Spontaneous Changes in Attentional Capabilities and Reasoning After an Alcohol Rehabilitation Treatment: Evidence About the Role of Age and Alcohol Use.Neuropsychiatric disease and treatment · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural bases of cognitive impairment(s) in alcohol use disorders (AUDs) might reflect either a global brain damage underlying different neuro-cognitive alterations, or the involvement of specific regions mostly affected by alcohol neuro-toxic effects. While voxel-based-morphometry (VBM) studies have shown a distributed atrophic pattern in fronto-limbic and cerebellar structures, the lack of comprehensive neuro-cognitive assessments prevents previous studies from drawing robust inferences on the specificity of the association between neuro-structural and cognitive impairments in AUDs. To fill this gap, we addressed the neuro-structural bases of cognitive impairment in AUDs, by coupling VBM with an in-depth neuropsychological assessment. VBM results highlighted a diffuse pattern of grey matter reduction in patients, involving the key-nodes of the meso-cortico-limbic (striatum, hippocampus, medial prefrontal cortex), salience (insular and dorsal anterior cingulate cortex) and executive (inferior frontal cortex) networks. Grey matter density in the insular and anterior cingulate sectors of the salience network, significantly decreased in patients, explained almost half of variability in their defective attentional and working-memory performance. The multiple cognitive and neurological impairments observed in AUDs might thus reflect a specific executive deficit associated with the selective damage of a salience-based neural mechanism enhancing access to cognitive resources required for controlled cognition and behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.