Evidence map›Paper›PMID 30262862›Full record

ArticleCell death & disease2018

Modulation of intracellular calcium signaling by microRNA-34a-5p.

Caroline Diener, Martin Hart, Dalia Alansary, Vanessa Poth, Barbara Walch-Rückheim, Jennifer Menegatti, Friedrich Grässer, Tobias Fehlmann, Stefanie Rheinheimer, Barbara A Niemeyer and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Trials and Tribulations of MicroRNA Therapeutics.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Neuronal microRNAs safeguard ER CaCellular and molecular life sciences : CMLS · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. miR-34a as hub of T cell regulation networks.Journal for immunotherapy of cancer · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Caroline DienerInstitute of Human Genetics, Saarland University, 66421, Homburg, Germany. caroline.diener@uni-saarland.de.ORCID http://orcid.org/0000-0002-3222-8419
Martin HartInstitute of Human Genetics, Saarland University, 66421, Homburg, Germany.
Dalia AlansaryMolecular Biophysics, Center for Integrative Physiology and Molecular Medicine, School of Medicine, Saarland University, 66421, Homburg, Germany.
Vanessa PothMolecular Biophysics, Center for Integrative Physiology and Molecular Medicine, School of Medicine, Saarland University, 66421, Homburg, Germany.
Barbara Walch-RückheimInstitute of Virology and Center of Human and Molecular Biology, Saarland University, 66421, Homburg, Germany.
Jennifer MenegattiInstitute of Virology and Center of Human and Molecular Biology, Medical School, Saarland University, 66421, Homburg, Germany.
Friedrich GrässerInstitute of Virology and Center of Human and Molecular Biology, Medical School, Saarland University, 66421, Homburg, Germany.
Tobias FehlmannChair for Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.
Stefanie RheinheimerInstitute of Human Genetics, Saarland University, 66421, Homburg, Germany.
Barbara A NiemeyerMolecular Biophysics, Center for Integrative Physiology and Molecular Medicine, School of Medicine, Saarland University, 66421, Homburg, Germany.ORCID http://orcid.org/0000-0002-6963-0575
Hans-Peter LenhofCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123, Saarbrücken, Germany.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-5361-0895
Eckart MeeseInstitute of Human Genetics, Saarland University, 66421, Homburg, Germany.
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca

Indexed as

ApoptosisCalcineurinCalciumCalcium ChannelsCalcium SignalingCell LineCell Line, TumorHEK293 CellsHumansInterleukin-2Jurkat CellsLymphocyte ActivationMicroRNAsNFATC Transcription FactorsSignal TransductionT-LymphocytesCalcineurinCalciumCalcium ChannelsInterleukin-2MicroRNAsMIRN34 microRNA, humanNFATC Transcription Factors

Identifiers

PMID30262862
PMCPMC6160487
OpenAlexW2893500368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.