ReviewEmerging microbes & infections2018
Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis.
Review in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Toxoplasma gondii seroprevalence among pregnant women in Africa: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- A fresh look at the role of spiramycin in preventing a neglected disease: meta-analyses of observational studies.European journal of medical research · 2021Pooled it
- Acute Toxoplasma infection in pregnant women worldwide: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.PLoS neglected tropical diseases · 2024Trial
- Using dried blood spots to estimate Toxoplasma gondii seroprevalence in pregnant women in Catalonia, Spain, and to serologically diagnose congenital toxoplasmosis.PLoS neglected tropical diseases · 2026Article
- Fatal Congenital Toxoplasmosis with Progressive Liver Failure and Genomic Characterization of a Novel Isolate from the United States.Microorganisms · 2025Article
- Protective Effect of S-Methylcysteine Against Toxoplasma gondii-Induced Reproductive Toxicity in Female Albino Rats.Acta parasitologica · 2025Article
- Latent toxoplasmosis and preeclampsia: evidence for the role of chronic infection in pregnancy complications.BMC pregnancy and childbirth · 2025Article
- A Major Facilitator Superfamily Transporter Is Critical for the Metabolism and Biogenesis of the Apicoplast.Pathogens (Basel, Switzerland) · 2025Article
- Diseases Caused by and Behaviors Associated withPathogens (Basel, Switzerland) · 2024Review
- Serological and molecular survey of Toxoplasma Gondii in aborted livestock fetuses from Northeast Iran.BMC research notes · 2024Article
- REIV-TOXO Project: Results from a Spanish cohort of congenital toxoplasmosis (2015-2022). The beneficial effects of prenatal treatment on clinical outcomes of infected newborns.PLoS neglected tropical diseases · 2024Observational
- Article
- Knowledge Gaps and Educational Opportunities in Congenital Toxoplasmosis: A Narrative Review of Brazilian and Global Perspectives.Tropical medicine and infectious disease · 2024Review
- In defense of children's brain: reshuffling the laboratory toolbox for the diagnosis of congenital toxoplasmosis.Journal of clinical microbiology · 2024Article
- Employing digital PCR for enhanced detection of perinatal Toxoplasma gondii infection: A cross-sectional surveillance and maternal-infant outcomes study in El Salvador.PLoS neglected tropical diseases · 2024Article
- Gestational toxoplasmosis treatment changes the child's prognosis: A cohort study in southern Brazil.PLoS neglected tropical diseases · 2023Article
- Congenital toxoplasmosis among hospitalized infants in Poland in the years 2007-2021: study based on the national hospital registry.Scientific reports · 2023Article
- MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.PLoS biology · 2023Article
- Toxoplasma gondii vaccine candidates: a concise review.Irish journal of medical science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Globally, congenital toxoplasmosis remains a significant cause of morbidity and mortality, and outbreaks of infection with T. gondii represent a significant, emerging public health burden, especially in the developing world. This parasite is a threat to public health. Disease often is not recognized and is inadequately managed. Herein, we analyze the status of congenital toxoplasmosis in Morocco, Colombia, the United States, and France. We identify the unique challenges faced by each nation in the implementation of optimal approaches to congenital toxoplasmosis as a public health problem. We suggest that developed and developing countries use a multipronged approach, modeling their public health management protocols after those in France. We conclude that education, screening, appropriate treatment, and the development of novel modalities will be required to intervene successfully in caring for individuals with this infection. Gestational screening has been demonstrated to be cost-effective, morbidity-sparing, and life-saving. Recognition of the value and promise of public health interventions to prevent human suffering from this emerging infection will facilitate better patient and societal outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.