ArticleInternational journal of molecular sciences2018
In Vivo Analysis of the Biocompatibility and Macrophage Response of a Non-Resorbable PTFE Membrane for Guided Bone Regeneration.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Different Membranes on Vertical Bone Regeneration: A Systematic Review and Network Meta-Analysis.BioMed research international · 2022Pooled it
- Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options.BioMed research international · 2021Pooled it
- Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026Review
- Article
- Isolation, Characterization and Biological Evaluation of Collagen fromMarine drugs · 2026Article
- Biological and clinical responses to dense and expanded PTFE membranes in alveolar ridge preservation: A prospective non-randomized cohort study with ex vivo analyses.Clinical oral investigations · 2026Observational
- Molecular Biointerface Characterization for an Implanted Medical Device Using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS).ACS applied materials & interfaces · 2026Article
- Effect of Poly (Lactic Acid/ε-Caprolactone) Bilayer Membrane on Tooth Extraction Socket Wound Healing in a Rat Model.Materials (Basel, Switzerland) · 2025Article
- Osteogenesis Activity and Porosity Effect of Biodegradable Mg-Ga Alloys Barrier Membrane for Guided Bone Regeneration: An in Vitro and in Vivo Study in Rabbits.Biomedicines · 2025Article
- Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review.Tissue engineering and regenerative medicine · 2025Review
- Histological Evaluation of Subcutaneous Tissue Reactions to a Novel Bilayer Polycaprolactone/Silk Fibroin/Strontium Carbonate Nanofibrous Membrane for Guided Bone Regeneration: A Study in Rabbits.Clinical and experimental dental research · 2025Article
- Bioactive Composite Membranes: Preclinical Analysis of PBAT/BAGNb Composition to Enhance the Quality of Guided Bone Regeneration.ACS applied materials & interfaces · 2025Article
- The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial.Journal of functional biomaterials · 2025Article
- Innovation and Development in Polymer Heart Valves: A New Era of Transcatheter Aortic Valve Replacement.European cardiology · 2025Review
- Developments in Alloplastic Bone Grafts and Barrier Membrane Biomaterials for Periodontal Guided Tissue and Bone Regeneration Therapy.International journal of molecular sciences · 2024Review
- Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair.Stem cell research & therapy · 2024Article
- The Association of Nanostructured Carbonated Hydroxyapatite with Denatured Albumin and Platelet-Rich Fibrin: Impacts on Growth Factors Release and Osteoblast Behavior.Journal of functional biomaterials · 2024Article
- The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes.Frontiers in bioengineering and biotechnology · 2024Article
- An effective device to enable consistent scratches for in vitro scratch assays.BMC biotechnology · 2023Article
- On the Various Numerical Techniques for the Optimization of Bone Scaffold.Materials (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of non-resorbable polytetrafluoroethylene (PTFE) membranes is indicated for the treatment of large, non-self-containing bone defects, or multi-walled defects in the case of vertical augmentations. However, less is known about the molecular basis of the foreign body response to PTFE membranes. In the present study, the inflammatory tissue responses to a novel high-density PTFE (dPTFE) barrier membrane have preclinically been evaluated using the subcutaneous implantation model in BALB/c mice by means of histopathological and histomorphometrical analysis methods and immunohistochemical detection of M1- and M2-macrophages. A collagen membrane was used as the control material. The results of the present study demonstrate that the tissue response to the dPTFE membrane involves inflammatory macrophages, but comparable cell numbers were also detected in the implant beds of the control collagen membrane, which is known to be biocompatible. Although these data indicate that the analyzed dPTFE membrane is not fully bioinert, but its biocompatibility is comparable to collagen-based membranes. Based on its optimal biocompatibility, the novel dPTFE barrier membrane may optimally support bone healing within the context of guided bone regeneration (GBR).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.