ArticleNanomaterials (Basel, Switzerland)2018
Biocompatible Nanocomposite Implant with Silver Nanoparticles for Otology-In Vivo Evaluation.
Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Antimicrobial efficacy and bonding properties of orthodontic bonding systems enhanced with silver nanoparticles: a systematic review with meta-analysis.BMC oral health · 2024Pooled it
- Use of Antimicrobial Silver Coatings on Fixed Orthodontic Appliances, Including Archwires, Brackets, and Microimplants: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2024Pooled it
- Silver Nanoparticles (AgNPs) as a Double-Edged Sword: Synthesis, Factors Affecting, Mechanisms of Toxicity and Anticancer Potentials-An Updated Review till March 2025.Biological trace element research · 2026Review
- Microstructural and Surface Texture Evaluation of Orthodontic Microimplants Covered with Bioactive Layers Enriched with Silver Nanoparticles.Journal of functional biomaterials · 2024Article
- Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures.Nanomaterials (Basel, Switzerland) · 2024Review
- Effect of Er:YAG Pulsed Laser-Deposited Hydroxyapatite Film on Titanium Implants on M2 Macrophage Polarization In Vitro and Osteogenesis In Vivo.International journal of molecular sciences · 2023Article
- In Vitro and In Vivo Studies of Antibacterial Coatings on Titanium Alloy Implants for Veterinary Application.International journal of molecular sciences · 2023Article
- G-Optrode Bio-Interfaces for Non-Invasive Optical Cell Stimulation: Design and Evaluation.Biosensors · 2022Article
- Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties.International journal of molecular sciences · 2022Review
- Green synthesis of Silver nanoparticles usingSaudi journal of biological sciences · 2022Article
- Bactericidal and Fungistatic Properties of LDPE Modified with a Biocide Containing Metal Nanoparticles.Materials (Basel, Switzerland) · 2021Article
- Article
- Nanoparticles for the Treatment of Inner Ear Infections.Nanomaterials (Basel, Switzerland) · 2021Review
- Exceptional antibacterial and cytotoxic potency of monodisperse greener AgNPs prepared under optimized pH and temperature.Scientific reports · 2021Article
- Thermoplastic Polymers with Nanosilver Addition-Microstructural, Surface and Mechanical Evaluation during a 36-Month Deionized Water Incubation Period.Materials (Basel, Switzerland) · 2021Article
- Synthesis of Dimethyl Octyl Aminoethyl Ammonium Bromide and Preparation of Antibacterial ABS Composites for Fused Deposition Modeling.Polymers · 2020Article
- Surface and Structural Properties of Medical Acrylonitrile Butadiene Styrene Modified with Silver Nanoparticles.Polymers · 2020Article
- State-of-Art Bio-Assay Systems and Electrochemical Approaches for Nanotoxicity Assessment.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- Long-Term Stability of Two Thermoplastic Polymers Modified with Silver Nanoparticles.Nanomaterials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this work was to investigate of biocompatibility of polymeric implants modified with silver nanoparticles (AgNPs). Middle ear prostheses (otoimplants) made of the (poly)acrylonitrile butadiene styrene (ABS) and ABS modified with silver nanoparticles were prepared through extrusion and injection moulding process. The obtained prostheses were characterized by SEM-EDX, micro-CT and mechanical tests, confirming their proper shape, good AgNPs homogenization and mechanical parameters stability. The biocompatibility of the implants was evaluated in vivo on rats, after 4, 12, 24 and 48 weeks of implantation. The tissue-healing process and cytotoxicity of the implants were evaluated on the basis of microscopic observations of the materials morphology after histochemical staining with cytochrome c oxidase (OCC) and acid phosphatase (AP), as well as via micro-tomography (ex vivo). The in vivo studies confirmed biocompatibility of the implants in the surrounding tissue environment. Both the pure ABS and nanosilver-modified ABS implants exhibited a distinct decrease in the area of granulation tissue which was replaced with the regenerating muscle tissue. Moreover, a slightly smaller area of granulation tissue was observed in the surroundings of the silver-doped prosthesis than in the case of pure ABS prosthesis. The kinetics of silver ions releasing from implants was investigated by ICP-MS spectrometry. The measurement confirmed that concentration of the silver ions increased within the implant's immersion period. Our results showed that middle ear implant with the nanoscale modification is biocompatible and might be used in ossicular reconstruction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.