Evidence map›Paper›PMID 30262665›Full record

ArticleThe Journal of biological chemistry2018

Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice.

Jun Wang, Tao Shen, Wuqiang Zhu, Longyu Dou, Hao Gu, Lingling Zhang, Zhenyun Yang, Hanying Chen, Qi Zhou, Edwin R Sánchez and 7 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Mechanisms of systolic heart failure in PP2CxPP5 double transgenic mice.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Plk4 Is a Novel Substrate of Protein Phosphatase 5.International journal of molecular sciences · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Jun WangFrom the Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China,; School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China.
Tao ShenDeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030.
Wuqiang ZhuHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Longyu DouFrom the Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China.
Hao GuFrom the Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China.
Lingling ZhangFrom the Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China.
Zhenyun YangHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Hanying ChenHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Qi ZhouHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Edwin R SánchezDepartment of Physiology and Pharmacology, College of Medicine, University of Toledo, Toledo, Ohio 43614, and.
Loren J FieldHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Lindsey D MayoHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Zhongwen XieSchool of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China.
Deyong XiaoFountain Valley Institute of Life Sciences and Fountain Valley Biomedical Technology Company, Dalian Hi-Tech Industrial Zone, Dalian 116023, China.
Xia LinDeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030.
Weinian ShouHerman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202,. Electronic address: wshou@iu.edu.
Weidong YongFrom the Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China,; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202,. Electronic address: wyong@cnilas.org.
Indiana University School of MedicineChinese Academy of Medical Sciences & Peking Union Medical College · CNAnhui Agricultural University · CNBaylor College of Medicine · USUniversity of Toledo · US

Funding

Transcriptional regulation of cardiac morphogenesisP01HL134599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Lei Yang · 2017 to 2026
$25.7M
Transcriptional regulation of cardiac conduction system morphogenesisR01HL145060 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIRULLI, ANTHONY B., SHOU, WEINIAN · 2019 to 2022
$2.8M
Cardiomyocyte cell cycle activity in injured heartsR01HL132927 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIELD, LOREN J · 2017 to 2020
$1.6M
NHLBI NIH HHS P01 HL134599NHLBI NIH HHS R01 HL132927NHLBI NIH HHS R01 HL145060
6 · The paper itself

Abstract

Protein phosphatase 5 (PP5), a serine/threonine phosphatase, has a wide range of biological functions and exhibits elevated expression in tumor cells. We previously reported that

Indexed as

Amino Acid MotifsAnimalsCyclin-Dependent Kinase Inhibitor p21DNA DamageDown-RegulationMiceMice, Inbred C57BLNuclear ProteinsPhosphoprotein PhosphatasesPromoter Regions, GeneticProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p21Mdm2 protein, mouseNuclear ProteinsPhosphoprotein Phosphatasesprotein phosphatase 5Proto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53cancercell stressgene knockoutp53posttranslational regulationprotein phosphatase 5protein phosphorylationprotein serine/threonine phosphatase (PSP)transcriptional regulationtumorigenesis

Identifiers

PMID30262665
PMCPMC6254348
OpenAlexW2894354453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.