ArticleProceedings of the National Academy of Sciences of the United States of America2018
Axonal plasticity associated with perceptual learning in adult macaque primary visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective.Frontiers in neural circuits · 2025Pooled it
- Advances in behavioral vision training for the treatment of childhood amblyopia: a narrative review.Translational pediatrics · 2026Review
- Motivational state determines error-sensitive learning modes in visual perceptual learning.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Perceptual learning improves discrimination but does not reduce distortions in appearance.PLoS computational biology · 2025Article
- Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.Nature neuroscience · 2024Article
- An essential role for the latero-medial secondary visual cortex in the acquisition and retention of visual perceptual learning in mice.Nature communications · 2024Article
- Dynamics of mature myelin.Nature neuroscience · 2024Review
- Electrical stimulation of the cuneiform nucleus enhances the effects of rehabilitative training on locomotor recovery after incomplete spinal cord injury.Frontiers in neuroscience · 2024Article
- The phase of plasticity-induced neurochemical changes of high-frequency repetitive transcranial magnetic stimulation are different from visual perceptual learning.Scientific reports · 2023Article
- Cellular computation and cognition.Frontiers in computational neuroscience · 2023Article
- Toward reframing brain-social dynamics: current assumptions and future challenges.Frontiers in psychiatry · 2023Review
- Subclass-specific expression patterns of MET receptor tyrosine kinase during development in medial prefrontal and visual cortices.The Journal of comparative neurology · 2023Article
- An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays.Journal of neural engineering · 2022Article
- Patients with first-episode untreated schizophrenia who experience concomitant visual disturbances and auditory hallucinations exhibit co-impairment of the brain and retinas-a pilot study.Brain imaging and behavior · 2021Article
- Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques.PLoS biology · 2020Article
- Improved fidelity of orientation perception: a learning effect dissociable from enhanced discriminability.Scientific reports · 2020Article
- Ventral midbrain stimulation induces perceptual learning and cortical plasticity in primates.Nature communications · 2019Article
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Authors and funding
4 authors.
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Abstract
Perceptual learning is associated with changes in the functional properties of neurons even in primary sensory areas. In macaque monkeys trained to perform a contour detection task, we have observed changes in contour-related facilitation of neuronal responses in primary visual cortex that track their improvement in performance on a contour detection task. We have previously explored the anatomical substrate of experience-dependent changes in the visual cortex based on a retinal lesion model, where we find sprouting and pruning of the axon collaterals in the cortical lesion projection zone. Here, we attempted to determine whether similar changes occur under normal visual experience, such as that associated with perceptual learning. We labeled the long-range horizontal connections in visual cortex by virally mediated transfer of genes expressing fluorescent probes, which enabled us to do longitudinal two-photon imaging of axonal arbors over the period during which animals improve in contour detection performance. We found that there are substantial changes in the axonal arbors of neurons in cortical regions representing the trained part of the visual field, with sprouting of new axon collaterals and pruning of preexisting axon collaterals. Our findings indicate that changes in the structure of axonal arbors are part of the circuit-level mechanism of perceptual learning, and further support the idea that the learned information is encoded at least in part in primary visual cortex.
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