Evidence map›Paper›PMID 30262649›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Mechanism of tRNA-mediated +1 ribosomal frameshifting.

Samuel Hong, S Sunita, Tatsuya Maehigashi, Eric D Hoffer, Jack A Dunkle, Christine M Dunham

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

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  4. Suppressor tRNA in gene therapy.Science China. Life sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Samuel HongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
S SunitaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Tatsuya MaehigashiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Eric D HofferDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Jack A DunkleDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
Christine M DunhamDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 christine.m.dunham@emory.edu.
Emory University · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Structural Studies of Ribosome RegulationR01GM093278 · NIGMS · EMORY UNIVERSITY · PI DUNHAM, CHRISTINE M · 2010 to 2022
$4.6M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
NCRR NIH HHS S10 RR029205NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM093278
6 · The paper itself

Abstract

Accurate translation of the genetic code is critical to ensure expression of proteins with correct amino acid sequences. Certain tRNAs can cause a shift out of frame (i.e., frameshifting) due to imbalances in tRNA concentrations, lack of tRNA modifications or insertions or deletions in tRNAs (called frameshift suppressors). Here, we determined the structural basis for how frameshift-suppressor tRNA

Indexed as

BacteriaCodonFrameshifting, RibosomalFrameshift MutationPeptide Elongation Factor GProtein BiosynthesisReading FramesRibosomesRNA, MessengerRNA, Ribosomal, 16SRNA, TransferCodonPeptide Elongation Factor GRNA, MessengerRNA, Ribosomal, 16SRNA, TransferframeshiftmRNArecodingribosometRNA

Identifiers

PMID30262649
PMCPMC6217423
OpenAlexW2893702172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.