Evidence map›Paper›PMID 30262565›Full record

ArticleHaematologica2019

T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing.

Cornelia S Link-Rachner, Anne Eugster, Elke Rücker-Braun, Falk Heidenreich, Uta Oelschlägel, Andreas Dahl, Christian Klesse, Matthias Kuhn, Jan Moritz Middeke, Martin Bornhäuser and 2 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

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  11. T cell regeneration after immunological injury.Nature reviews. Immunology · 2021
    Review
  12. Article
  13. Article
  14. T Cell Clonal Dynamics Determined by High-Resolution TCR-β Sequencing in Recipients after Allogeneic Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Cornelia S Link-RachnerMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden cornelia.link@uniklinikum-dresden.de.
Anne EugsterDFG Research Center for Regenerative Therapies Dresden, TU Dresden.
Elke Rücker-BraunMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Falk HeidenreichMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Uta OelschlägelMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Andreas DahlDFG Research Center for Regenerative Therapies Dresden, TU Dresden.
Christian KlesseDKMS Clinical Trials Unit, Dresden.
Matthias KuhnInstitut für Medizinische Informatik und Biometrie (IMB), Medizinische Fakultät der TU Dresden, Germany.
Jan Moritz MiddekeMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Martin BornhäuserMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Ezio BonifacioDFG Research Center for Regenerative Therapies Dresden, TU Dresden.
Johannes ScheteligMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, TU Dresden.
TU Dresden · DEDeutsche Knochenmarkspenderdatei · DEInstitut für Medizinische Biometrie, Informatik und Epidemiologie · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alloreactivity or opportunistic infections following allogeneic stem cell transplantation are difficult to predict and contribute to post-transplantation mortality. How these immune reactions result in changes to the T-cell receptor repertoire remains largely unknown. Using next-generation sequencing, the T-cell receptor alpha (TRα) repertoire of naïve and memory CD8

Indexed as

CD8-Positive T-LymphocytesFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHigh-Throughput Nucleotide SequencingHumansImmunologic MemoryLymphocyte DepletionMaleReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsTransplantation, HomologousReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID30262565
PMCPMC6395323
OpenAlexW2892660002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.