Evidence map›Paper›PMID 30262468›Full record

ArticleJournal of cell science2018

Spatial positioning of EB family proteins at microtubule tips involves distinct nucleotide-dependent binding properties.

Daniel Roth, Benjamin P Fitton, Nikola P Chmel, Natalia Wasiluk, Anne Straube

Open access · hybridAbstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 72 citations in OpenAlex.

  1. Tubulin flux at spastin-induced nanodamage sites regulates microtubule rescue frequency and EB1 lifetimes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. The microtubule GTP-tubulin cap size is modulated during cell division.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Phase separation of +TIP networks regulates microtubule dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. MAPping tubulin mutations.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel RothCentre for Mechanochemical Cell Biology (CMCB), University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0003-0064-8985
Benjamin P FittonCentre for Mechanochemical Cell Biology (CMCB), University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0003-3132-7965
Nikola P ChmelDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0002-2882-5253
Natalia WasilukCentre for Mechanochemical Cell Biology (CMCB), University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0002-0869-6247
Anne StraubeCentre for Mechanochemical Cell Biology (CMCB), University of Warwick, Coventry CV4 7AL, UK anne@mechanochemistry.org.ORCID 0000-0003-2067-9041
University of Warwick · GB

Funding

Wellcome Trust 200870/Z/16/Z
6 · The paper itself

Abstract

EB proteins track the ends of growing microtubules and regulate microtubule dynamics both directly and by acting as the hub of the tip-tracking network. Mammalian cells express cell type-specific combinations of three EB proteins with different cellular roles. Here, we reconstitute EB1, EB2 and EB3 tip tracking

Indexed as

Binding SitesHumansMicrotubule-Associated ProteinsMicrotubulesNucleotidesProtein BindingProtein DomainsSignal TransductionTubulinMicrotubule-Associated ProteinsNucleotidesTubulinEnd-binding proteinsMAPsMicrotubulesNucleotide stateTip trackingTubulin

Identifiers

PMID30262468
PMCPMC6398475
OpenAlexW2893327070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.