Evidence map›Paper›PMID 30262256›Full record

ArticleAutonomic neuroscience : basic & clinical2019

Direct neurophysiological evidence for a role of the human anterior cingulate cortex in central command.

Martin J Gillies, Yongzhi Huang, Jonathan A Hyam, Tipu Z Aziz, Alexander L Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autonomic neuroscience : basic & clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Distinct Brain Systems Support Afferent and Efferent Autonomic Activity.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Distinct brain systems support afferent and efferent autonomic activity.Social cognitive and affective neuroscience · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. A rationale for considering heart/brain axis control in neuropsychiatric disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  11. Mental Stress and Cardiovascular Health-Part I.Journal of clinical medicine · 2022
    Review
  12. Article
  13. D-Serine: A Cross Species Review of Safety.Frontiers in psychiatry · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Martin J GilliesNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK. Electronic address: martin.gillies@nds.ox.ac.uk.
Yongzhi HuangNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Jonathan A HyamNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK.
Tipu Z AzizNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Alexander L GreenNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
John Radcliffe Hospital · GBUniversity of Oxford · GB

Funding

British Heart Foundation PG/11/3/28555HSRD VA PEC 13-001
6 · The paper itself

Abstract

introductionThe role of the anterior cingulate cortex (ACC) is still controversial. The ACC has been implicated in such diverse functions as cognition, arousal and emotion in addition to motor and autonomic control. Therefore the ACC is the ideal candidate to orchestrate cardiovascular performance in anticipation of perceived skeletal activity. The aim of this experiment was to investigate whether the ACC forms part of the neural network of central command whereby cardiovascular performance is governed by a top-down mechanism. METHODS &

resultsDirect local field potential (LFP) recordings were made using intraparenchymal electrodes in six human ACC's to measure changes in neuronal activity during performance of a motor task in which anticipation of exercise was uncoupled from skeletal activity itself. Parallel cardiovascular arousal was indexed by electrocardiographic changes in heart rate. During anticipation of exercise, ACC LFP power within the 25-60 Hz frequency band increased significantly by 21% compared to rest (from 62.7 μV CONCLUSIONS/SIGNIFICANCE: We provide the first invasive electrophysiological evidence to support the role of the ACC in both motor preparation and the top-down control of cardiovascular function in exercise. This further implicates the ACC in the body's response to the outside world and its possible involvement in such extreme responses as emotional syncope and hyperventilation. In addition we describe the frequency at which the neuronal ACC populations perform these tasks in the human.

Indexed as

AdultAgedAnticipation, PsychologicalFemaleGyrus CinguliHeart RateHumansMaleMembrane PotentialsMiddle AgedNeuronsAnterior cingulate cortexCardiovascular systemDeep brain stimulationElectrophysiologyLocal field potentialsMotor system

Identifiers

PMID30262256
PMCPMC6314459
OpenAlexW2891810482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.