ArticleJournal of the International Society of Sports Nutrition2018
Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption.
Article in Journal of the International Society of Sports Nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Metabolomics analyses and physical interventions in soccer: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2024Pooled it
- Metabolomics in Exercise and Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Integrative Metabolomic and Echocardiographic Profiling Reveals Metabolic-Cardiac Structural Coupling in Yili Horses During Incremental Exercise.Animals : an open access journal from MDPI · 2026Article
- Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems.Scientific reports · 2025Article
- Nutritional Strategies for Enhancing Performance and Training Adaptation in Weightlifters.International journal of molecular sciences · 2024Review
- Exploring the association of physical activity with the plasma and urine metabolome in adolescents and young adults.Nutrition & metabolism · 2023Article
- Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments.Sports (Basel, Switzerland) · 2023Article
- Metabolomics in Team-Sport Athletes: Current Knowledge, Challenges, and Future Perspectives.Proteomes · 2022Review
- Article
- Future opportunities for the Athlete Biological Passport.Frontiers in sports and active living · 2022Article
- Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells.Frontiers in molecular biosciences · 2022Article
- Acute enteric-coated sodium bicarbonate has negligible effect on anaerobic performance but affects metabolomics and attenuates the gastrointestinal response.Frontiers in physiology · 2022Article
- Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players.Frontiers in molecular biosciences · 2021Article
- High Endurance Elite Athletes Show Age-dependent Lower Levels of Circulating Complements Compared to Low/Moderate Endurance Elite Athletes.Frontiers in molecular biosciences · 2021Article
- Comparison of the Metabolites of Water Polo Players before and after Competition by the Metabolomic Approach.Journal of healthcare engineering · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundSupplements are widely used among elite athletes to maintain health and improve performance. Despite multiple studies investigating use of dietary supplements by athletes, a comprehensive profiling of serum supplement metabolites in elite athletes is still lacking. This study aims to analyze the presence of various xenobiotics in serum samples from elite athletes of different sports, focusing on metabolites that potentially originate from nutritional supplements.
methodsProfiling of xenobiotics in serum samples from 478 elite athletes from different sports (football, athletics, cycling, rugby, swimming, boxing and rowing) was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography. Multivariate analysis was performed using orthogonal partial least squares discriminant analysis. Differences in metabolic levels among different sport groups were identified by univariate linear models.
resultsOut of the 102 detected xenobiotics, 21 were significantly different among sport groups including metabolites that potentially prolong exercise tolerance (caffeic acid), carry a nootropic effect (2-pyrrolidinone), exert a potent anti-oxidant effect (eugenol, ferulic acid 4 sulfate, thioproline, retinol), or originate from drugs for different types of injuries (ectoine, quinate). Using Gaussian graphical modelling, a metabolic network that links various sport group-associated xenobiotics was constructed to further understand their metabolic pathways.
conclusionsThis pilot data provides evidence that athletes from different sports exhibit a distinct xenobiotic profile that may reflect their drug/supplement use, diet and exposure to various chemicals. Because of limitation in the study design, replication studies are warranted to confirm results in independent data sets, aiming ultimately for better assessment of dietary supplement use by athletes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.