ArticleBMC plant biology2018
Arabidopsis ETHYLENE RESPONSE FACTOR 8 (ERF8) has dual functions in ABA signaling and immunity.
Article in BMC plant biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 77 citations in OpenAlex.
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- AP2/ERF transcription factors regulate the biosynthesis of terpenoids, phenolics, and alkaloids in plants.Horticulture research · 2026Article
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- Phylogenomic Analysis and Functional Characterization of the APETALA2/Ethylene-Responsive Factor Transcription Factor Across Solanaceae.International journal of molecular sciences · 2024Article
- Molecular Evolution of RAMOSA1 (RA1) in Land Plants.Biomolecules · 2024Article
- Plant disease resistance outputs regulated by AP2/ERF transcription factor family.Stress biology · 2024Review
- Transcriptome-based network analysis of cell cycle-related genes in response to blue and red light in maize.AoB PLANTS · 2023Article
- Transcript-wide identification and expression pattern analysis to comprehend the roles of AP2/ERF genes under development and abiotic stress in Trichosanthes kirilowii.BMC plant biology · 2023Article
- Sustained defense response via volatile signaling and its epigenetic transcriptional regulation.Plant physiology · 2022Article
- Smells like trouble: β-ocimene primes plant defenses through chromatin remodeling.Plant physiology · 2022Article
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- Plant Kinases in the Perception and Signaling Networks Associated With Arthropod Herbivory.Frontiers in plant science · 2022Review
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- Verticillium wilt resistant and susceptible olive cultivars express a very different basal set of genes in roots.BMC genomics · 2021Article
- Maize Ethylene Response FactorFrontiers in plant science · 2021Article
- Structural insights into Arabidopsis ethylene response factor 96 with an extended N-terminal binding to GCC box.Plant molecular biology · 2020Article
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundETHYLENE RESPONSE FACTOR (ERF) 8 is a member of one of the largest transcription factor families in plants, the APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) superfamily. Members of this superfamily have been implicated in a wide variety of processes such as development and environmental stress responses.
resultsIn this study we demonstrated that ERF8 is involved in both ABA and immune signaling. ERF8 overexpression induced programmed cell death (PCD) in Arabidopsis and Nicotiana benthamiana. This PCD was salicylic acid (SA)-independent, suggesting that ERF8 acts downstream or independent of SA. ERF8-induced PCD was abolished by mutations within the ERF-associated amphiphilic repression (EAR) motif, indicating ERF8 induces cell death through its transcriptional repression activity. Two immunity-related mitogen-activated protein kinases, MITOGEN-ACTIVATED PROTEIN KINASE 4 (MPK4) and MPK11, were identified as ERF8-interacting proteins and directly phosphorylated ERF8 in vitro. Four putative MPK phosphorylation sites were identified in ERF8, one of which (Ser103) was determined to be the predominantly phosphorylated residue in vitro, while mutation of all four putative phosphorylation sites partially suppressed ERF8-induced cell death in N. benthamiana. Genome-wide transcriptomic analysis and pathogen growth assays confirmed a positive role of ERF8 in mediating immunity, as ERF8 knockdown or overexpression lines conferred compromised or enhanced resistance against the hemibiotrophic bacterial pathogen Pseudomonas syringae, respectively.
conclusionsTogether these data reveal that the ABA-inducible transcriptional repressor ERF8 has dual roles in ABA signaling and pathogen defense, and further highlight the complex influence of ABA on plant-microbe interactions.
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