Evidence map›Paper›PMID 30261724›Full record

ArticleJournal of the American Chemical Society2018

Twelve-Step Asymmetric Synthesis of (-)-Nodulisporic Acid C.

Nicole A Godfrey, Devon J Schatz, Sergey V Pronin

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Cascade Cyclization ofACS omega · 2024
    Article
  5. Article
  6. Directed Hydrogen Atom Transfer for Selective Reactions of Polyenols.Journal of the American Chemical Society · 2024
    Article
  7. Article
  8. Synthesis of Pleuromutilin.Journal of the American Chemical Society · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. A Radical-Polar Crossover Annulation To Access Terpenoid Motifs.Journal of the American Chemical Society · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole A GodfreyDepartment of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Devon J SchatzDepartment of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Sergey V ProninDepartment of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0002-0202-9232

Funding

Synthesis of Antimitotic Paxilline Indole DiterpenesR01GM121678 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PRONIN, SERGEY · 2017 to 2021
$1.8M
NIGMS NIH HHS R01 GM121678
6 · The paper itself

Abstract

A short, enantioselective synthesis of (-)-nodulisporic acid C is described. The route features two highly diastereoselective polycyclizations en route to the terpenoid core and the indenopyran fragment and a highly convergent assembly of a challenging indole moiety. Application of this chemistry allows for a 12-step synthesis of the target indoloterpenoid from commercially available material.

Indexed as

Combinatorial Chemistry TechniquesCyclizationCycloaddition ReactionIndolesStereoisomerismTerpenesIndolesnodulisporic acid CTerpenes

Identifiers

PMID30261724
PMCPMC6791361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.