ReviewMarine drugs2018
Addressing the Issue of Tetrodotoxin Targeting.
Review in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Acute and sub-acute toxicity assessment of tetrodotoxin in Sprague-Dawley rats following intramuscular injection.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Effects of Tetrodotoxin on Safety, and Sensory and Respiratory Systems: A Dose-Escalating Study in Healthy Volunteers.European journal of pain (London, England) · 2026Article
- Females of tetrodotoxin-containing ribbon worms of Cephalothrix simula species complex (Palaeonemertea, Nemertea) keep high toxicity and produce toxic eggs during long-term captivity.Marine biotechnology (New York, N.Y.) · 2025Article
- Tetrodotoxin Delivery Pen Safely Uses Potent Natural Neurotoxin to Manage Severe Cutaneous Pain.Advanced healthcare materials · 2025Article
- Marine Toxins as Pharmaceutical Treasure Troves: A Focus on Saxitoxin Derivatives from a Computational Point of View.Molecules (Basel, Switzerland) · 2024Article
- Article
- Acute Toxic Effects of Tetrodotoxin in Mice via Intramuscular Injection and Oral Gavage.Toxins · 2023Article
- Natural Compounds and Products from an Anti-Aging Perspective.Molecules (Basel, Switzerland) · 2022Review
- Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins.Marine drugs · 2021Review
- Cyanotoxins and the Nervous System.Toxins · 2021Review
- From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic.Toxins · 2021Review
- Tetrodotoxin: A New Strategy to Treat Visceral Pain?Toxins · 2021Review
- Article
- Small cyclic sodium channel inhibitors.Biochemical pharmacology · 2021Article
- Analgesia Effect of Enteric Sustained-Release Tetrodotoxin Pellets in the Rat.Pharmaceutics · 2020Article
- Review
- Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin.Toxins · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This review is devoted to the medical application of tetrodotoxin (TTX), a potent non-protein specific blocker of voltage-gated sodium (NaV) channels. The selectivity of action, lack of affinity with the heart muscle NaV channels, and the inability to penetrate the blood⁻brain barrier make this toxin an attractive candidate for anesthetic and analgesic drug design. The efficacy of TTX was shown in neuropathic, acute and inflammatory pain models. The main emphasis of the review is on studies focused on the improvement of TTX efficacy and safety in conjunction with additional substances and drug delivery systems. A significant improvement in the effectiveness of the toxin was demonstrated when used in tandem with vasoconstrictors, local anesthetics and chemical permeation enhancers, with the best results obtained with the encapsulation of TTX in microparticles and liposomes conjugated to gold nanorods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.