ArticleNeuroImage. Clinical2018
Insight and emotion regulation in schizophrenia: A brain activation and functional connectivity study.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From risk to chronicity: genetic and neuroimaging insights into the evolving patterns of spontaneous brain activity in schizophrenia.Psychological medicine · 2025Pooled it
- In search of convergent regional brain abnormality in cognitive emotion regulation: A transdiagnostic neuroimaging meta-analysis.Human brain mapping · 2022Pooled it
- Neurophysiological evidence for emotion regulation abnormalities in individuals at clinical high-risk for psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Task fMRI paradigms may capture more behaviorally relevant information than resting-state functional connectivity.NeuroImage · 2023Article
- Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Review
- Abnormal Ventral Somatomotor Network Homogeneity in Patients With Temporal Lobe Epilepsy.Frontiers in psychiatry · 2022Article
- Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms.Frontiers in psychiatry · 2022Article
- Enhanced Resting-State Functional Connectivity of the Nucleus Accumbens in First-Episode, Medication-Naïve Patients With Early Onset Schizophrenia.Frontiers in neuroscience · 2022Article
- Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study.Neuropsychiatric disease and treatment · 2021Article
- Neurophysiological evidence for emotion regulation impairment in schizophrenia: The role of visual attention and cognitive effort.Journal of abnormal psychology · 2020Article
- Examining Specificity of Neural Correlates of Childhood Psychotic-like Experiences During an Emotional n-Back Task.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study.Frontiers in genetics · 2020Article
- Brain function differences in drug-naïve first-episode auditory verbal hallucination-schizophrenia patients with versus without insight.Chinese medical journal · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInsight is impaired in the majority of schizophrenia patients. The exact neural correlates of impaired insight remain unclear. We assume that the ability to regulate emotions contributes to having good clinical insight, as patients should be able to regulate their emotional state in such a way that they can adapt adequately in order to cope with impaired functioning and negative stigma associated with a diagnosis of schizophrenia. Numerous studies have shown emotional dysregulation in schizophrenia. We investigated the association between insight and brain activation and connectivity during emotion regulation.
methodsBrain activation during emotion regulation was measured with functional MRI in 30 individuals with schizophrenia. Two emotion regulation strategies were examined: cognitive reappraisal and expressive suppression. Clinical insight was measured with the Schedule for the Assessment of Insight - Expanded, and cognitive insight was measured with the Beck Cognitive Insight Scale. Whole brain random effects multiple regression analyses were conducted to assess the relation between brain activation during emotion regulation and insight. Generalized psychophysiological interaction (gPPI) was used to investigate the relation between task-related connectivity and insight.
resultsNo significant associations were found between insight and neural correlates of cognitive reappraisal. For clinical insight and suppression, significant positive associations were found between symptom relabeling and activation in the left striatum, thalamus and insula, right insula and caudate, right pre- and postcentral gyrus, left superior occipital gyrus and cuneus and right middle and superior occipital gyrus and cuneus. Furthermore, reduced clinical insight was associated with more connectivity between midline medial frontal gyrus and right middle occipital gyrus. For cognitive insight and suppression, significant positive associations were found between self-reflectiveness and activation in pre- and postcentral gyrus and left middle cingulate gyrus.
conclusionsOur results suggest an association between the capacity to relabel symptoms and activation of brain systems involved in cognitive-emotional control and visual processing of negative stimuli. Furthermore, poorer self-reflectiveness may be associated with brain systems subserving control and execution.
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