Evidence map›Paper›PMID 30261247›Full record

ArticleExperimental gerontology2018

Reduced motor cortex inhibition and a 'cognitive-first' prioritisation strategy for older adults during dual-tasking.

Daniel T Corp, George J Youssef, Ross A Clark, Joyce Gomes-Osman, Meryem A Yücel, Stuart J Oldham, Shatha Aldraiwiesh, Jordyn Rice, Alvaro Pascual-Leone, Mark A Rogers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  16. Brain activity during dual-task standing in older adults.Journal of neuroengineering and rehabilitation · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Daniel T CorpCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC 3125, Australia; Berenson-Allen Center for Non-Invasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: daniel.corp@deakin.edu.au.
George J YoussefCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC 3125, Australia; Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Australia.
Ross A ClarkSchool of Health and Sports Science, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.
Joyce Gomes-OsmanBerenson-Allen Center for Non-Invasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Physical Therapy, University of Miami Miller School of Medicine, Miami, FL, USA.
Meryem A YücelAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Stuart J OldhamBrain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton 3168, VIC, Australia.
Shatha AldraiwieshDepartment of Physical Therapy, University of Miami Miller School of Medicine, Miami, FL, USA.
Jordyn RiceDepartment of Physical Therapy, University of Miami Miller School of Medicine, Miami, FL, USA.
Alvaro Pascual-LeoneBerenson-Allen Center for Non-Invasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Mark A RogersCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC 3125, Australia.
Beth Israel Deaconess Medical Center · USUniversity of Miami · USDeakin University · AUHarvard University · USUniversity of the Sunshine Coast · AU

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Cortical Plasticity in Autism Spectrum DisordersR01MH100186 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROTENBERG, ALEXANDER · 2014 to 2018
$2.2M
Cortical connectivity, physiology, and response to stimulation in human epilepsyR01NS073601 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHANG, BERNARD S. · 2011 to 2015
$1.9M
Role of functional brain connectivity on efficacy of TMS for depressionR21MH099196 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$491k
Cortical plasticity in type II diabetes mellitusR21NS082870 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$490k
Transcranial Stimulation in Spino-Cerebellar AtaxiaR21NS085491 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$469k
NCATS NIH HHS KL2 TR002737NCRR NIH HHS UL1 RR025758NICHD NIH HHS R01 HD069776NIMH NIH HHS R01 MH100186NIMH NIH HHS R21 MH099196NINDS NIH HHS R01 NS073601NINDS NIH HHS R21 NS082870NINDS NIH HHS R21 NS085491
6 · The paper itself

Abstract

It is well established that older adults are less able to perform attentionally demanding motor tasks, placing them at greater risk of accident-related injury. The primary purpose of this study was to investigate whether the interplay between prefrontal and motor cortex activity could predict such age-related performance deficits. Using a dual-task (DT) paradigm, 15 younger and 15 older adults participated in experiment 1, where brain activity was simultaneously measured using functional near infrared spectroscopy (fNIRS) and transcranial magnetic stimulation (TMS). Experiment 1 demonstrated poorer performance for the older group across a range of DTs combining visuomotor arm tracking with a secondary cognitive or motor task. Interestingly however, older adults' DT performance error was isolated to the motor component of DTs. TMS data revealed reduced motor cortex (M1) inhibition during DTs for older adults, and a trend for this correlating with poorer performance. In contrast, poorer performing younger adults showed significantly higher M1 inhibition. Experiment 2 was conducted given a high amount of movement artifact in experiment 1 fNIRS data. Using fNIRS to measure prefrontal, premotor, and motor cortex activity in an additional 15 older adults, we found no evidence of an interplay between these regions predicting DT performance. Nevertheless, performance data replicated experiment 1 in showing that DT error was isolated to motor tasks in older adults, with no significant cognitive task error. Overall, this study shows that older adults seemed to adopt a 'cognitive-first' prioritisation strategy during the DTs involved in our study, and that deficits in DT performance may be related to the modulation of M1 inhibitory mechanisms. We propose that clinicians advise older adults to allocate greater attention to motor tasks during activities where they may be at risk of accident-related injury.

Indexed as

Transcranial Magnetic StimulationAdultAgedAgingExecutive FunctionFemaleHumansMaleMiddle AgedMotor CortexPsychomotor PerformanceSpectroscopy, Near-InfraredTask Performance and AnalysisYoung AdultDual-taskInhibitionPrefrontal cortexPrimary motor cortexPrioritisation

Identifiers

PMID30261247
PMCPMC6263161
OpenAlexW2894091391

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.