Evidence map›Paper›PMID 30261161›Full record

ArticleJournal of molecular and cellular cardiology2018

Phospholamban regulates nuclear Ca

Mu Chen, Dongzhu Xu, Adonis Z Wu, Evangelia Kranias, Shien-Fong Lin, Peng-Sheng Chen, Zhenhui Chen

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  9. Review
  10. Article
  11. CaPflugers Archiv : European journal of physiology · 2022
    Review
  12. Article
  13. CaCell calcium · 2020
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Mu ChenKrannert Institute of Cardiology, Indiana University, Indianapolis, IN, USA; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dongzhu XuKrannert Institute of Cardiology, Indiana University, Indianapolis, IN, USA; Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Adonis Z WuKrannert Institute of Cardiology, Indiana University, Indianapolis, IN, USA.
Evangelia KraniasDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Shien-Fong LinKrannert Institute of Cardiology, Indiana University, Indianapolis, IN, USA; Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsin-Chu, Taiwan.
Peng-Sheng ChenKrannert Institute of Cardiology, Indiana University, Indianapolis, IN, USA.
Zhenhui ChenKrannert Institute of Cardiology, Indiana University, Indianapolis, IN, USA. Electronic address: zhechen@iu.edu.
Indiana University – Purdue University Indianapolis · USIndiana University Health · USNational Yang Ming Chiao Tung University · TWShanghai Jiao Tong University · CNUniversity of Cincinnati Medical Center · USUniversity of Tsukuba · JP

Funding

TARGETED ABLATION AND ALTERATION OF MOUSE PHOSPHOLAMBANR01HL026057 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 1985 to 2017
$5.3M
SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
Subcutaneous nerve stimulation for arrhythmia control.U18TR002208 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2017 to 2018
$1.4M
NCATS NIH HHS U18 TR002208NHLBI NIH HHS R01 HL026057NHLBI NIH HHS R01 HL139829
6 · The paper itself

Abstract

aimsPhospholamban (PLB) is the key regulator of the cardiac Ca METHODS AND

resultsFluo-4 based confocal Ca

conclusionPLB regulates nuclear Ca

Indexed as

Calcium SignalingAnimalsCalciumCalcium-Binding ProteinsCell NucleusDogsInositol 1,4,5-TrisphosphateMiceMice, KnockoutMolecular ImagingMyocytes, CardiacPermeabilityPhospholambanSarcoplasmic ReticulumTetracaineCalciumCalcium-Binding ProteinsInositol 1,4,5-TrisphosphatePhospholambanTetracaine1,4,5-Trisphosphate receptorCalcium signalingCardiomyocyteNuclear Ca(2+) dynamicsNuclear membranesPhospholambanSarcoplasmic reticulum Ca(2+) cycling

Identifiers

PMID30261161
PMCPMC6205300
OpenAlexW2893974250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.