Evidence map›Paper›PMID 30261154›Full record

ReviewCell adhesion & migration2019

Recapitulation of molecular regulators of nuclear motion during cell migration.

Alexandra Sneider, Jungwon Hah, Denis Wirtz, Dong-Hwee Kim

Open access · goldAbstract readReview
In one paragraph

Review in Cell adhesion & migration, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Cyclic stretch inhibits cell invasion in 3D scaffolds.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Cellular Features Revealed by Transverse Laser Modes in Frequency Domain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alexandra Sneidera Department of Chemical and Biomolecular Engineering , Johns Hopkins University , Baltimore , MD , USA.
Jungwon Hahb KU-KIST Graduate School of Converging Science and Technology , Korea University , Seoul , Republic of Korea.
Denis Wirtza Department of Chemical and Biomolecular Engineering , Johns Hopkins University , Baltimore , MD , USA.
Dong-Hwee Kimb KU-KIST Graduate School of Converging Science and Technology , Korea University , Seoul , Republic of Korea.ORCID 0000-0003-0625-0660
Johns Hopkins University · USKorea University · KR

Funding

The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI SUN, SEAN X · 2016 to 2020
$9.9M
Single-cell phenotyping for therapeutic stratification in pancreatic cancerR01CA174388 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2012 to 2016
$3.8M
NCI NIH HHS R01 CA174388NCI NIH HHS U54 CA210173
6 · The paper itself

Abstract

Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

Indexed as

Cell MovementCellular MicroenvironmentCytoskeletonAnimalsCell NucleusHumansCell migrationCytoskeletonLINC complexNuclear mechanics

Identifiers

PMID30261154
PMCPMC6527386
OpenAlexW2894098116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.