Evidence map›Paper›PMID 30261149›Full record

ArticleHuman vaccines & immunotherapeutics2019

Incident genital HPV infections and potential impact of HPV vaccines in adult women living with HIV/AIDS.

Giovanna Orlando, Elena R Frati, Michela M Fasolo, Silvia Bianchi, Alberto Matteelli, Francesca Mazza, Giuliano Rizzardini, Antonella Amendola, Elisabetta Tanzi

Open access · hybridAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Giovanna Orlandoa Infectious Diseases Outpatient Unit, Centro Diagnostico Italiano (CDI) , Milan , Italy.ORCID 0000-0002-1462-3247
Elena R Fratib Department of Biomedical Sciences for Health, University of Milan , Milan , Italy.ORCID 0000-0001-7021-2525
Michela M Fasoloc STD Unit, Infectious Diseases 1st, L Sacco University Hospital , Milan , Italy.ORCID 0000-0001-7207-5800
Silvia Bianchib Department of Biomedical Sciences for Health, University of Milan , Milan , Italy.ORCID 0000-0002-1365-9408
Alberto Matteellid Department of Infectious and Tropical Diseases, University of Brescia , Brescia , Italy.ORCID 0000-0001-5109-9248
Francesca Mazzae U.O. Laboratorio Analisi, ASST Santi Paolo e Carlo , Milan , Italy.ORCID 0000-0002-4733-1232
Giuliano Rizzardinif Infectious Diseases 1st, L Sacco University Hospital , Milan , Italy.ORCID 0000-0002-5183-7818
Antonella Amendolab Department of Biomedical Sciences for Health, University of Milan , Milan , Italy.ORCID 0000-0002-0499-8977
Elisabetta Tanzib Department of Biomedical Sciences for Health, University of Milan , Milan , Italy.ORCID 0000-0002-4119-701X
University of Milan · ITLuigi Sacco Hospital · ITAzienda Socio Sanitaria Territoriale Santi Paolo e CarloCentro Diagnostico Italiano · ITUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to describe and characterize incident HR-HPV infections and associated diseases in HIV-infected women. 805 HIV-infected women enrolled in the VALHIDATE Study were screened and followed-up for HPV by co-testing. Social, behavioral and health data were collected. HPV-DNA positive samples were typed using a commercial kit or RFLP analysis. Conventional Pap-smears were evaluated using the 2001 Bethesda System. The participants with abnormal cytological results were referred for colposcopy. 565 HIV-infected women (median age: 43 years) were analysed, 40.9% had >5 lifetime sexual partners, 77.2% contracted HIV through sexual intercourse, 93% were receiving antiretroviral treatment and 77.3% had undetectable HIV-RNA. The women underwent 1254 follow-ups (median follow-up: 33 months) for 1430.6 PersonYear-Follow-Up. 37.4% of baseline HPV-negative women acquired incident HPV-infections, 69.6% of which were HR-HPVs. HPV-53 was the most common HPV type detected (9.3%). 18.2% of women showed incident or progressive cytological abnormalities (7.8% ASC-US, 9.7% LSIL and 0.6% HSIL) and colposcopy revealed CIN2 (N = 2), CIN1 (N = 2) and VIN3 (N = 1). The preventable fraction of incident infections was 11.3%, 16.7%, and 35.2% for the 2v-4v-9v-HPV vaccines respectively (χ

Indexed as

AdultDNA, ViralFemaleFollow-Up StudiesGenital Diseases, FemaleGenotypeHIV InfectionsHumansItalyMiddle AgedPapillomavirus InfectionsPapillomavirus VaccinesUterine Cervical DysplasiaUterine Cervical NeoplasmsDNA, ViralPapillomavirus VaccinescytologyHPV incident infectionsHPV vaccinesHR-HPVWomen living with HIV/AIDS

Identifiers

PMID30261149
PMCPMC6746504
OpenAlexW2893454647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.