ArticlePloS one2018
Inactivation of human and avian influenza viruses by potassium oleate of natural soap component through exothermic interaction.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Differential mechanisms of SARS-CoV-2 inactivation by anionic surfactants: a comparative study of fatty acid salts and synthetic surfactants.Scientific reports · 2026Article
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- The SARS-CoV-2 Hydra, a tiny monster from the 21st century: Thermodynamics of the BA.5.2 and BF.7 variants.Microbial risk analysis · 2023Article
- Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy.Nanomaterials (Basel, Switzerland) · 2023Article
- Development of a Propidium Monoazide-Based Viability Quantitative PCR Assay for Red Sea Bream Iridovirus Detection.International journal of molecular sciences · 2023Article
- Review
- Complex formation of potassium salt of highly fatty acid with hemagglutinin protein in influenza virus via exothermic interaction.Biochemistry and biophysics reports · 2022Article
- Liquid-Immersion Reprocessing Effects on Filtration Efficiency of 'Single-Use' Commercial Medical Face Masks.Annals of work exposures and health · 2022Article
- Effects of Hand Hygiene Using 4% Chlorhexidine Gluconate or Natural Soap During Hand Rubbing Followed by Alcohol-Based 1% Chlorhexidine Gluconate Sanitizer Lotion in the Operating Room.Advances in wound care · 2022Article
- Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.Journal of oral microbiology · 2022Article
- Capsid integrity RT-qPCR for the selective detection of intact SARS-CoV-2 in wastewater.The Science of the total environment · 2021Article
- Surfactants - Compounds for inactivation of SARS-CoV-2 and other enveloped viruses.Current opinion in colloid & interface science · 2021Review
- The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity.Scientific reports · 2021Article
- Knowledge, Attitudes, and Risk Perception Toward Avian Influenza Virus Exposure Among Cuban Hunters.Frontiers in public health · 2021Article
- Hand hygiene during COVID-19: Recommendations from the American Contact Dermatitis Society.Journal of the American Academy of Dermatology · 2020Review
- Analysis of Inactivation of SARS-CoV-2 by Specimen Transport Media, Nucleic Acid Extraction Reagents, Detergents, and Fixatives.Journal of clinical microbiology · 2020Article
- Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus ReplicationEvidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An influenza epidemic is still a problem despite the development of vaccines and anti-influenza drugs. Preventive measures such as handwashing are fundamental and important for counteracting influenza virus infection. In this study, we clarified the anti-influenza virus effects of surfactants, which are the main components of hand soaps for hand washing: potassium oleate (C18:1), sodium laureth sulfate (LES) and sodium lauryl sulfate (SDS). For a human influenza virus strain (H3N2), C18:1 reduced the infectivity by 4 logs or more, whereas LES and SDS reduced the infectivity by 1 log or less. Similar results were obtained when an avian influenza virus strain (H5N3) was used. The interaction between the surfactant and virus was then investigated by isothermal titration calorimetry. The LES-virus system showed a positive value of enthalpy changes (ΔH), meaning an exothermic interaction that indicated a hydrophobic interaction. In contrast, both the C18:1-virus system and the SDS-virus system showed negative values of ΔH, meaning an endothermic interaction that indicated an electrical interaction. The ΔH value of the C18:1-virus system was much higher than that of the SDS-virus system. A mixture of C18:1 and HA proteins similarly showed negative values of ΔH. These results indicate that influenza virus inactivation by a hydrophobic interaction of a surfactant with the viral envelope is insufficient to prevent infection, whereas inactivation by an electrical interaction of a surfactant with HA proteins is sufficient to prevent influenza virus infection.
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