ArticlePloS one2018
X-ray dark-field imaging of the human lung-A feasibility study on a deceased body.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Multi-contrast X-ray microtomography of human lung specimens with an extended field-of-view.Medical physics · 2026Article
- Advanced X-Ray Imaging Technology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- How X-ray dark-field imaging relates to small-angle X-ray scattering measurements.Journal of applied crystallography · 2025Article
- Realistic wave-optics simulation of X-ray dark-field imaging at a human scale.Scientific reports · 2025Article
- Lung volume assessment for mean dark-field coefficient calculation using different determination methods.European radiology experimental · 2025Article
- X-ray dark-field computed tomography for monitoring of tissue freezing.Scientific reports · 2024Article
- X-ray dark-field chest radiography: a reader study to evaluate the diagnostic quality of attenuation chest X-rays from a dual-contrast scanning prototype.European radiology · 2023Article
- The choice of an autocorrelation length in dark-field lung imaging.Scientific reports · 2023Article
- Self-aligned multi-layer X-ray absorption grating using large-area fabrication methods for X-ray phase-contrast imaging.Scientific reports · 2023Article
- Dark-field X-ray imaging for the assessment of osteoporosis in human lumbar spine specimens.Frontiers in physiology · 2023Article
- Assessment of Inflation in a Human Cadaveric Lung with Dark-Field Chest Radiography.Radiology. Cardiothoracic imaging · 2022Article
- Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances.World journal of radiology · 2022Review
- Image guidance for FLASH radiotherapy.Medical physics · 2022Article
- Dark-field tomography of an attenuating object using intrinsic x-ray speckle tracking.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Retrieval of 3D information in X-ray dark-field imaging with a large field of view.Scientific reports · 2021Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study.Scientific reports · 2021Article
- Edge-illumination x-ray phase-contrast imaging.Journal of physics. Condensed matter : an Institute of Physics journal · 2021Review
- Correlation of image quality parameters with tube voltage in X-ray dark-field chest radiography: a phantom study.Scientific reports · 2021Article
- High-resolution multicontrast tomography with an X-ray microarray anode-structured target source.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disorders of the lungs such as chronic obstructive pulmonary disease (COPD) are a major cause of chronic morbidity and mortality and the third leading cause of death in the world. The absence of sensitive diagnostic tests for early disease stages of COPD results in under-diagnosis of this treatable disease in an estimated 60-85% of the patients. In recent years a grating-based approach to X-ray dark-field contrast imaging has shown to be very sensitive for the detection and quantification of pulmonary emphysema in small animal models. However, translation of this technique to imaging systems suitable for humans remains challenging and has not yet been reported. In this manuscript, we present the first X-ray dark-field images of in-situ human lungs in a deceased body, demonstrating the feasibility of X-ray dark-field chest radiography on a human scale. Results were correlated with findings of computed tomography imaging and autopsy. The performance of the experimental radiography setup allows acquisition of multi-contrast chest X-ray images within clinical boundary conditions, including radiation dose. Upcoming clinical studies will have to demonstrate that this technology has the potential to improve early diagnosis of COPD and pulmonary diseases in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.