Evidence map›Paper›PMID 30260776›Full record

Trial reportThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2018

Comparison of 10 and 14 days of triple therapy versus 10 days of sequential therapy for Helicobacter pylori eradication: A prospective randomized study.

Abulgasim Ennkaa, Nabeel Shaath, Abdul Salam, Ramzi M Mohammad

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. The cost-effectiveness of sequential versus standard triple therapy forSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Trial
  3. Sequential versus Standard Triple Therapy for First-LineAntibiotics (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abulgasim EnnkaaDepartment of Gastroenterology, Hamad Medical Corporation Al Wakra Hospital, Doha, Qatar.
Nabeel ShaathDepartment of Gastroenterology, Hamad Medical Corporation Al Wakra Hospital, Doha, Qatar.
Abdul SalamAcademic Health System, Hamad Medical Corporation, Doha, Qatar.
Ramzi M MohammadTranslational Research Institute, Hamad Medical Corporation, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe aim of the present study was to compare between the efficacy and tolerability of a sequential therapy (ST) as the first-line treatment for adults with Helicobacter pylori infection and that of standard triple therapy (TT). MATERIALS AND

methodsThis was a prospective, randomized open-label, single-center study. We enrolled 206 patients who were divided into the following three treatment groups: Group A (pantoprazole 40 mg bid (twice daily), amoxicillin 1 g bid, and clarithromycin 500 mg bid for 10 d), Group B (the same TT as Group A for 14 d), and Group C (pantoprazole 40 mg bid and amoxicillin 1 g bid for 5 d, followed by pantoprazole 40 mg bid, clarithromycin 500 mg bid, and metronidazole 500 mg bid for additional 5 d).

resultsIntention-to-treat (ITT) analysis revealed that 14 d of TT achieved a higher eradication rate than 10 d of ST (54.8% vs. 50.7%), but the difference was not statistically significant (p=0.623); further, 10 d of TT achieved 45% eradication rate. Per-protocol (PP) analysis revealed that the success rate for 10 d of ST was more than that for 10 d of TT (70.6% vs. 65%; p=0.571); however, the success rate for 10 d of TT was not statistically different from that for 14 d of TT. The eradication rates achieved in the ITT analysis were lower than those achieved in the PP analysis for 10 (45% vs. 65%) or 14 (54.7% vs. 69%) d of TT or for 10 d of ST (50.7% vs. 70.6%). No statistically significant difference was observed. Adverse effects and compliance were not significantly different among the three groups.

conclusionNeither 10 d of ST nor 14 d of TT achieved the optimum H. pylori eradication rate.

Indexed as

AdultAmoxicillinAnti-Bacterial AgentsAnti-Ulcer AgentsClarithromycinDrug Administration ScheduleDrug Therapy, CombinationFemaleHelicobacter InfectionsHelicobacter pyloriHumansIntention to Treat AnalysisMaleMetronidazoleMiddle AgedPantoprazoleAmoxicillinAnti-Bacterial AgentsAnti-Ulcer AgentsClarithromycinMetronidazolePantoprazole

Identifiers

PMID30260776
PMCPMC6284607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.