ArticleJournal of magnetic resonance imaging : JMRI2019
3D MR Elastography of Hepatocellular Carcinomas as a Potential Biomarker for Predicting Tumor Recurrence.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 82 citations in OpenAlex.
- Nomogram based on clinical and preoperative CT features for predicting the early recurrence of combined hepatocellular-cholangiocarcinoma: a multicenter study.La Radiologia medica · 2023Trial
- Tissue Strain Mapping via Magnetic Resonance Elastography Can Be Used to Detect Active Lesion Expansion.Magnetic resonance in medicine · 2026Article
- Feasibility of multifrequency MR elastography of the seminal vesicles in healthy men, benign prostatic hyperplasia, and prostate cancer.European radiology experimental · 2026Article
- [Research advances of magnetic resonance elastography for assessing the bioinvasiveness in hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Machine learning integrating MRI and clinical features predicts early recurrence of hepatocellular carcinoma after resection.Scientific reports · 2026Article
- Comparative study of 3D MR elastography and intravoxel incoherent motion for the evaluation of hepatocellular carcinoma grade.Liver research (Beijing, China) · 2025Article
- MR Elastography for Classification of Focal Liver Lesions Using Viscoelastic Parameters: A Pilot Study Based on Intrinsic and Extrinsic Activations.Journal of magnetic resonance imaging : JMRI · 2025Article
- Magnetic Resonance Elastography Combined With PI-RADS v2.1 for the Identification of Clinically Significant Prostate Cancer.Journal of magnetic resonance imaging : JMRI · 2025Article
- CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression.Journal of translational medicine · 2025Article
- Diffusion-based virtual MR elastography for predicting recurrence of solitary hepatocellular carcinoma after hepatectomy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma.Scientific reports · 2024Article
- Viscoelastic parameters derived from multifrequency MR elastography for depicting hepatic fibrosis and inflammation in chronic viral hepatitis.Insights into imaging · 2024Article
- Linking cell mechanical memory and cancer metastasis.Nature reviews. Cancer · 2024Review
- Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma.Insights into imaging · 2023Article
- Magnetic resonance elastography for noninvasive detection of liver fibrosis: is there an added value of 3D acquisition?Abdominal radiology (New York) · 2023Article
- Stiffness on shear wave elastography as a potential microenvironment biomarker for predicting tumor recurrence in HBV-related hepatocellular carcinoma.Insights into imaging · 2023Article
- Thyroid artery embolization of large solitary symptomatic benign thyroid nodules through transradial approach.Quantitative imaging in medicine and surgery · 2023Article
- The value of quantitative MR elastography-based stiffness for assessing the microvascular invasion grade in hepatocellular carcinoma.European radiology · 2023Article
- Crosstalk of ferroptosis and oxidative stress in infectious diseases.Frontiers in molecular biosciences · 2023Review
- Perioperative predictors of outcome of hepatectomy for HBV-related hepatocellular carcinoma.Frontiers in oncology · 2023Review
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPreoperative prediction of tumor recurrence is important in the management of patients with hepatocellular carcinoma (HCC). PURPOSE: To investigate whether tumor stiffness derived by magnetic resonance elastography (MRE) could predict early recurrence of HCC after hepatic resection. STUDY TYPE: Retrospective. POPULATION: In all, 99 patients with pathologically confirmed HCCs after surgical resection. FIELD STRENGTH/SEQUENCE: 3.0T; preoperative MRE with 60-Hz mechanical vibrations using an active acoustic driver. ASSESSMENT: Regions of interest (ROIs) were manually drawn in the tumors to measure mean tumor stiffness. Surgical specimens were reviewed for histological grade, capsule, vascular invasion, and surgical margins. The early recurrence of HCC was defined as that occurring within 2 years after resection. STATISTICAL TESTS: Cox proportional hazard models were used to evaluate risk factors associated with the time to early recurrence.
resultsHCCs with recurrence had higher tumor stiffness, higher rate of advanced T stage, vascular invasion, lower rate of capsule formation, larger tumor size, higher aspartate aminotransferase (AST), and hepatitis B virus (HBV)-DNA level and aspartate aminotransferase / alanine aminotransferase ratio (P = 0.031, 0.007, 0.01, <0.001, 0.015, 0.034, 0.01, and 0.014, respectively) than HCCs without recurrence. Vascular invasion (hazard ratio [HR] = 2.922; 95% confidence interval [CI]: [1.079, 7.914], P = 0.035) and mean tumor stiffness (HR = 1.163; 95% CI: [1.055, 1.282], P = 0.002) were risk factors associated with early recurrence. Each 1-kPa increase in tumor stiffness was associated with a 16.3% increase in the risk for tumor recurrence. DATA
conclusionThe mean stiffness of HCCs may be a useful, noninvasive, quantitative biomarker for the prediction of early HCC recurrence after hepatic resection. LEVEL OF EVIDENCE: 4 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019;49:719-730.
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