Evidence map›Paper›PMID 30260499›Full record

ArticleJournal of leukocyte biology2019

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

Chantal Donovan, Malcolm R Starkey, Richard Y Kim, Batika M J Rana, Jillian L Barlow, Bernadette Jones, Tatt Jhong Haw, Prema Mono Nair, Kurtis Budden, Guy J M Cameron and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Cigarette smoke components modulate the MR1-MAIT axis.The Journal of experimental medicine · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Comparison of cell subsets in chronic obstructive pulmonary disease and controls based on single-cell transcriptome sequencing.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Heterogeneity of ILC2s in the Lungs.Frontiers in immunology · 2022
    Review
  18. Crosstalk between ILC2s and Th2 CD4Journal of immunology research · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Chantal DonovanPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Malcolm R StarkeyPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Richard Y KimPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Batika M J RanaMedical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Jillian L BarlowMedical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Bernadette JonesPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Tatt Jhong HawPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Prema Mono NairPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Kurtis BuddenPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Guy J M CameronPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Jay C HorvatPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Peter A WarkPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Paul S FosterPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Andrew N J McKenzieMedical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Philip M HansbroPriority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Hunter Medical Research Institute · AUMedical Research Council · GBCentenary Institute · AUMRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105178805Medical Research Council U105178805MRC UK U105178805Wellcome Trust 100963Wellcome Trust 100963/Z/13/Z
6 · The paper itself

Abstract

Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and B lymphocytes and group 2 innate lymphoid cells (ILC2s) in airway inflammation and remodelling, and lung function in an experimental model of COPD using mice that specifically lack these cells (Rag1

Indexed as

Immunity, InnateAirway RemodelingAirway ResistanceAnimalsB-LymphocytesBody WeightCell CountCollagenHomeodomain ProteinsInterleukinsMice, Inbred C57BLPneumoniaPulmonary AlveoliPulmonary Disease, Chronic ObstructiveRespiratory HypersensitivityT-LymphocytesCollagenHomeodomain ProteinsInterleukinsRAG-1 proteinCOPDemphysemaILC2sinflammationremodellingT cells

Identifiers

PMID30260499
PMCPMC6487813
OpenAlexW2893612159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.