ArticleJournal of radiation research2019
The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats.
Article in Journal of radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.Medical gas researchTrial
- Protective role of rosmarinic acid against radiation-induced dermatitis: focus on oxidative stress and inflammation.BMC complementary medicine and therapies · 2026Article
- Effect of hydrogen-enriched water on healing of excisional full-layer skin wounds in diabetic and non-diabetic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Molecular Hydrogen in the Treatment of Respiratory Diseases.International journal of molecular sciences · 2025Review
- Progress in the Application of Molecular Hydrogen in Medical Skin Cosmetology.Clinical, cosmetic and investigational dermatology · 2025Review
- Therapeutic Potential of Hydrogen as a Radioprotective Agent for the Prevention of Radiation Dermatitis.Antioxidants (Basel, Switzerland) · 2024Article
- Prospects of molecular hydrogen in cancer prevention and treatment.Journal of cancer research and clinical oncology · 2024Review
- Health Benefits of Electrolyzed Hydrogen Water: Antioxidant and Anti-Inflammatory Effects in Living Organisms.Antioxidants (Basel, Switzerland) · 2024Review
- Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats.BMC molecular and cell biology · 2023Article
- Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.Antioxidants (Basel, Switzerland) · 2023Review
- Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway.Oxidative medicine and cellular longevity · 2022Article
- The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs.Veterinary sciences · 2021Article
- Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.International journal of molecular sciences · 2021Review
- Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo.Journal of radiation research · 2021Article
- Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis.Oncology letters · 2020Article
- Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.Journal of bioenergetics and biomembranes · 2019Article
- Hydrogen Gas in Cancer Treatment.Frontiers in oncology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to determine the healing effect of hydrogen-rich water (HRW) on radiotherapy-induced skin injury. Rats were irradiated with a 6 MeV electron beam from a Varian linear accelerator. After skin wound formation, rats were individually administrated with distilled water, HRW (1.0 ppm) or HRW (2.0 ppm). We measured the healing time and observed the healing rate of the wounded surface. After irradiation, the malondialdehyde (MDA) content and the superoxide dismutase (SOD) activity in the wounded tissues were evaluated, as determined using an MDA and SOD assay kit. Interleukin-6 (IL-6) and epidermal growth factor (EGF) levels were assessed by enzyme-linked immunosorbent assay (ELISA). Models of skin damage were successfully established using a 44 Gy electronic beam. The healing time was shortened in the two HRW-treated groups (P < 0.05). Furthermore, interventions of HRW resulted in a marked reduction in the MDA (P < 0.05) and IL-6 levels (P < 0.01). Additionally, the SOD activity in the two HRW-treated groups was higher than that in the distilled water group at the end of the 1st, 2nd and 3rd weeks (P < 0.001). The EGF level was also significantly increased at the end of the 1st and 2nd weeks (P < 0.05). Compared with the HRW (1.0 ppm) group, the healing rate was higher and the healing time was reduced in the HRW (2.0 ppm) group. A significant decrease was observed in the IL-6 level at the end of the 1st, 3rd and 4th weeks (P < 0.05) and in the EGF content at the end of the 1 week after the HRW administration (P < 0.01). Collectively, our data indicate that HRW accelerates wound healing of radiation-induced skin lesions through anti-oxidative and anti-inflammatory effects, suggesting that HRW has a healing effect on acute radiation-mediated skin injury, and that this is dependent on the concentration of the hydrogen.
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