ArticleThe Journal of clinical endocrinology and metabolism2019
Postprandial Insulin Response and Clearance Among Black and White Women: The Federal Women's Study.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial.Diabetologia · 2025Trial
- Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults.The Journal of clinical endocrinology and metabolism · 2020Trial
- Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole-Body Fat Metabolism, and Organ-Specific Lipid Deposition.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Insulin Levels Early in Perimenopause Inform Vasomotor Symptom Incidence Across the Menopausal Transition.The Journal of clinical endocrinology and metabolism · 2026Article
- Insulin levels early in perimenopause inform vasomotor symptom incidence across the menopausal transition.medRxiv : the preprint server for health sciences · 2025Article
- Variations in weight loss and glycemic outcomes after sleeve gastrectomy by race and ethnicity.Obesity (Silver Spring, Md.) · 2025Article
- Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity.The Journal of clinical endocrinology and metabolism · 2025Article
- Polycystic ovary syndrome as a metabolic disease.Nature reviews. Endocrinology · 2025Review
- Estimating insulin sensitivity and β-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model.American journal of physiology. Endocrinology and metabolism · 2024Article
- Variation in the relationship between fasting glucose and HbA1c: implications for the diagnosis of diabetes in different age and ethnic groups.BMJ open diabetes research & care · 2024Article
- Diagnostic cut-off value of haemoglobin A1c for diabetes mellitus in Harare, Zimbabwe.African journal of laboratory medicine · 2024Article
- Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report.Diabetology & metabolic syndrome · 2023Article
- Physiologic hormone administration improves HbA1C in Native Americans with type 2 diabetes: A retrospective study and review of insulin secretion and action.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway.Molecular nutrition & food research · 2023Article
- Pathophysiology of type 2 diabetes in sub-Saharan Africans.Diabetologia · 2022Review
- Exploring the determinants of ethnic differences in insulin clearance between men of Black African and White European ethnicity.Acta diabetologica · 2022Article
- β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat.Endocrine connections · 2021Article
- Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2021Article
- Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men.BMJ open diabetes research & care · 2021Observational
- When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Context: Postprandial hyperinsulinemia might be an important cardiometabolic risk determinant in black compared with white women. However, the contributions of insulin clearance and β-cell function to racial differences in postprandial insulin response are unknown. Objective: To compare, by race and menopause, early insulin response to oral and intravenous glucose and to measure postprandial intact glucagon-like peptide 1 (GLP-1) concentrations, insulin clearance, and β-cell function. Design and Participants: 119 federally employed women without diabetes [87 premenopausal (52 black, 35 white) and 32 postmenopausal (19 black, 13 white)] underwent an oral glucose tolerance test, insulin-modified frequently sampled intravenous glucose test (IM-FSIGT), and mixed meal tolerance test (MMTT). Outcome Measures: Early insulin response was measured as follows: (i) insulinogenic index (oral glucose tolerance test); (ii) acute insulin response to glucose (IM-FSIGT); and (iii) ratio of incremental insulin/glucose area under the curve in the first 30 minutes of the MMTT. Insulin clearance was assessed during the IM-FSIGT and MMTT. During the MMTT, intact GLP-1 was measured and β-cell function assessed using the insulin secretion rate and β-cell responsivity indexes. Results: Black pre-menopausal and postmenopausal women had a greater insulin response and lower insulin clearance and greater dynamic β-cell responsivity (P ≤ 0.05 for all). No differences were found in the total insulin secretion rates or intact GLP-1 concentrations. Conclusions: Greater postprandial hyperinsulinemia in black pre-menopausal and postmenopausal women was associated with lower hepatic insulin clearance and heightened β-cell capacity to rapid changes in glucose, but not to higher insulin secretion. The relationship of increased β-cell secretory capacity, reduced insulin clearance, and ambient hyperinsulinemia to the development of cardiometabolic disease requires further investigation.
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Registered trials
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