ArticleeLife2018
Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- All-optical closed-loop control of human cardiomyocyte networks exploiting holographic optogenetics.Communications engineering · 2026Article
- Hidden Spirals Reveal the Neurocomputational Mechanisms of Traveling Waves in Human Memory.bioRxiv : the preprint server for biology · 2026Article
- Termination of figure-of-eight reentry via resonant feedback pacing.Frontiers in network physiology · 2025Article
- Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Impact of Combined Modulation of Two Potassium Ion Currents on Spiral Waves and Turbulent States in the Heart.Entropy (Basel, Switzerland) · 2024Article
- Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Opto-electronic feedback control of membrane potential for real-time control of action potentials.Cell reports methods · 2023Article
- Dissolution of spiral wave's core using cardiac optogenetics.PLoS computational biology · 2023Article
- In silico optical modulation of spiral wave trajectories in cardiac tissue.Pflugers Archiv : European journal of physiology · 2023Article
- A micro-LED array based platform for spatio-temporal optogenetic control of various cardiac models.Scientific reports · 2023Article
- Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies.Biomimetics (Basel, Switzerland) · 2023Review
- Structure and function of the parvoviral NS1 protein: a review.Virus genes · 2023Review
- Spatial distribution of heterogeneity as a modulator of collective dynamics in pancreatic beta-cell networks and beyond.Frontiers in network physiology · 2023Article
- Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Optogenetic Control of Human Induced Pluripotent Stem Cell-Derived Cardiac Tissue Models.Journal of the American Heart Association · 2022Article
- Optogenetics for light control of biological systems.Nature reviews. Methods primers · 2022Article
- Pulsed low-energy stimulation initiates electric turbulence in cardiac tissue.PLoS computational biology · 2021Article
- Spatiotemporal development of coexisting wave domains of Rho activity in the cell cortex.Scientific reports · 2021Article
- Topological braiding and virtual particles on the cell membrane.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Propagation of non-linear waves is key to the functioning of diverse biological systems. Such waves can organize into spirals, rotating around a core, whose properties determine the overall wave dynamics. Theoretically, manipulation of a spiral wave core should lead to full spatiotemporal control over its dynamics. However, this theory lacks supportive evidence (even at a conceptual level), making it thus a long-standing hypothesis. Here, we propose a new phenomenological concept that involves artificially dragging spiral waves by their cores, to prove the aforementioned hypothesis in silico, with subsequent in vitro validation in optogenetically modified monolayers of rat atrial cardiomyocytes. We thereby connect previously established, but unrelated concepts of spiral wave attraction, anchoring and unpinning to demonstrate that core manipulation, through controlled displacement of heterogeneities in excitable media, allows forced movement of spiral waves along pre-defined trajectories. Consequently, we impose real-time spatiotemporal control over spiral wave dynamics in a biological system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.